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上海酶联生物研究所
上海酶联生物研究所
阅读：806发布时间：2010-4-9
*昆明动物研究所赖仞研究员与*上海药物研究所林东海研究员领导的研究团队在多肽类抗氧化系统研究方面再获新进展。
2009年，该研究团队提出了基因编码的多肽类抗氧化系统，并命名为“第三套”抗氧化系统。在“第三套”抗氧化系统工作的基础上，该研究团队从多肽类抗氧化系统对自由基的清除效率、速度以及作用机理进行了深入研究，结果表明抗氧化多肽可以非常快速地清除80%以上人造自由基（小于两秒钟），其速度是目前商业用抗氧化剂（如2，6-二叔丁基-4-甲基*和*）的2-4倍。抗氧化作用机制研究表明，抗氧化多肽序列中的还原性半*对快速地清除自由基起着关键作用。
该研究结果发表在美国《自由基生物医学联合会会刊》。
原文出处：
Free Radical Biology and Medicine doi:10.1016/j.freeradbiomed.2010.01.036
Frog skins keep redox homeostasis by antioxidant peptides with rapid radical scavenging ability
Cunbao Liua, b, 1, Jing Hongb, c, 1, Hailong Yanga, b, 1, Jing Wua, b, Dongying Maa, b, Dongsheng Lia, Donghai Linc, , and Ren Laia, d
a Biotoxin Unit of the Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, Yunnan, China
b Graduate School, Chinese Academy of Sciences, Beijing, China
c Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
d Key Laboratory of Microbiological Engineering of the Agricultural Environment, Ministry of Agriculture, Life Sciences College, Nanjing Agricultural University, Nanjing, Jiangsu, China
The question of how amphibians can protect themselves from reactive oxygen species when exposed to the sun in an oxygen-rich atmosphere is important and interesting, not only from an evolutionary viewpoint, but also as a primer for researchers interested in mammalian skin biology, in which such peptide systems for antioxidant defense are not well studied. The identification of an antioxidant peptide named antioxidin-RL from frog （Odorrana livida） skin in this report supports the idea that a peptide antioxidant system may be a widespread antioxidant strategy among amphibian skins. Its ability to eliminate most of the 2,2′-azino-bis（3-ethylbenzthiazoline-6-sulfonic acid） radical tested within 2 s, which is much faster than the commercial antioxidant factor butylated hydroxytoluene, suggests that it has a potentially large impact on redox homeostasis in amphibian skins. Cys10 is proven to be responsible for its rapid radical scavenging function and tyrosines take part in the binding of antioxidin-RL to radicals according to our nuclear magnetic resonance assay.
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