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IP-10 (human, recombinant), [125I]-, Bolton-Hunter Labeled, 5µCi

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珀金埃尔默医学诊断产品（上海）有限公司

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产品简介

Interferon gamma-induced protein 10 (IP-10; CXCL10), labeled with 125I. IP-10 binds the chemokine CXCR3 receptor, and is secreted in response to IFN-γ.

详细介绍

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX348:

Gao, J.M., Xiang, R.L., Jiang, L., Li, W.H., Feng, Q.P., Guo, Z.J., Sun, Q., Zeng, Z.P., Fang, F.D. (2009), Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10. Acta Pharmacol Sin., 30 (2): 193-201.
Jenh, C.H., Cox, M.A., Hipkin, W., Lu, T., Pugliese-Sivo, C., Gonsiorek, W., Chou, C.C., Narula, S.K., Zavodny, P.J. (2001), Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. Cytokine, 15 (3): 113-121.

规格

浓度	41.4 µCi/mL
检测方法	Radiometric
新鲜的很多天	Third Monday of each month
标签位置	Nominally Labeled
产品品牌名称	NEN Radiolabeled Ligands
放射性同位素	I-125
放射性核素	¹²⁵I
受体类型	Chemokine
运输条件	干冰
特殊订购信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域	Inflammation
产品尺寸	5 µCi