Anti-Sclerostin抗体,骨形态发生抑制蛋白SOST
英文介绍：Negative regulator of bone growth.Sclerostin (SOST) is a bone morphogenetic protein (BMP) antagonist, leading to the activation of BMP signaling. It negatively regulates the formation of bone by repressing the differentiation and/or function of osteoblasts induced by BMPs. It has been shown that Sclerostin binds BMP-5, -6, and -7 with high affinity and BMP-2 and -4 with low affinity. The noggin-sclerostin protein complex represents a novel mechanism for the fine-tuning of BMP activity in bone homeostasis. Evidence is accumulating that one of the important mechanisms of bone regulation by sclerostin is the modulation of Wnt/Beta-catenin signaling. Sclerostin also rapidly activated ERK-1/2 MAPK signaling, indicating the involvement of additional signaling pathways.
此产品本公司有标记的一抗出售，相关标记有：Alexa Fluor 350 标记、Alexa Fluor 488 标记、Alexa Fluor 555 标记、Alexa Fluor 647 标记、AP标记、APC标记、Biotin标记、Cy3标记、Cy5标记、Cy5.5标记、Cy7标记、FITC标记、Gold标记、HRP标记、PE标记、PE-Cy3标记、PE-CY5标记、PE-CY5.5标记、PE-CY7标记、RBITC标记
注意事项:This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品名称：Anti-Sclerostin抗体,骨形态发生抑制蛋白SOST
产品编号：BYK-6194R
英文名称：Anti-Sclerostin
中文名称：骨形态发生抑制蛋白SOST抗体
英文别名：BEER; Cortical hyperostosis with syndactyly; Sclerosteosis; Sclerostin; SOST; SOST_HUMAN; VBCH.
产品规格：0.1ml/0.2ml
此抗体本公司有单抗和多抗，可用于免疫组化（IHC），免疫印迹（WB），酶联免疫(ELISA)，IF、IP、流式细胞术等实验（可来电索取说明）
保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
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Anti-Sclerostin抗体,骨形态发生抑制蛋白SOST封闭(Blocking):
转膜完毕后，立即把蛋白膜放置到预先准备好的Western洗涤液中，漂洗1-2分钟，以洗去膜上的转膜液。从转膜完毕后所有的步骤，一定要注意膜的保湿，避免膜的干燥，否则极易产生较高的背景。
用微型台式真空泵吸尽洗涤液，加入Western封闭液，在摇床上缓慢摇动,室温封闭60分钟。对于一些背景较高的抗体，可以在4℃ 封闭过夜。
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