电子测痛仪也叫做电子触觉测试仪，用于对大鼠、小鼠足部进行轻触，来测量老鼠的机械痛阈值或触觉阈值。
老鼠感觉到爪子被刺激时，会做出缩足反应。电子触觉测试仪使用测试探针对老鼠足底进行触觉刺激，力度由小到大逐渐增加力度，通过判断老鼠的缩足反应，来采集和分析老鼠的触觉阈值。
纤毛机械刺激丝套装。但是纤毛机械刺激丝的方法非常耗时耗力，一个测试实验需要使用多个不同纤维丝进行多次和反复足底刺激。
Von Frey电子测痛仪的主要规格
· 提供三种测试量程90g、800g和1000g；
· 支持多个用户用一个个体支持做多个研究；
· 有刚性探针和软丝可供选择；
· 刚性测试探针可用率评估机械痛（阈值）
· 软性探针可用来测试感官阈值；
主要型号和配置
· 2390型测试量程90g，精度0.01g
· 2091型测试量程800g，精度0.1g
· 23931型测试量程1000g，精度0.1g
· 2392型包含90g测试量程的2390测试仪和1套Supertips测试软丝
· 2393型包含800g测试量程的2091型测试仪和1套Supertips测试软丝
· 115VFHS15件套Supertips测试软丝
· 110RT标准测试探头
电子触觉测试仪可用来替代传统的 Semmes-Weinstein（Von Frey Hairs）纤毛机械刺激针，可直接测得动物的机械痛阈和触觉阈测量，不需要进行反复的测试和繁杂的计算。设备轻巧易用，测量精确。
电子触觉测试仪相比传统方法的优势特点
· 电子触觉测试仪，一个测试实验只需要进行一次足底刺激即可得到准确的结果；
· 数据可直接用于统计分析，能够节省很多的精力和时间；
· 测量精度高，测试力度能够读取到1000g以内的具体数值，精度可达0.1g；
· 不需要进行繁杂的统计和计算；
· 使用一个标准直径的刚性探针进行测试，能够避免不同力度纤维丝具有不同的直径而产生的触觉误差；
· 能够避免因为反复多次的测试对动物耐受力的影响，减小测试误差；
|
人体触觉测试 |
小鼠足底触觉测试 |
Electric Von Frey电子测痛仪的主要参数
· 配备通用的接头，测试手柄可插入三种不同规格的探针
· 标配LCD显示屏(Floating or last max. & minimum)
· 刚性探头能达800Gr；
· 可选配Supertips软性测试丝，规格15-65Gr；
· 探针兼容MRI环境；
· 电子微处理器兼容0.1Gr插入式探针；
· 测试丝耐潮，耐温；
· 可选配模拟输出线；
· 可根据实际需要定制探针；
· 具有测量、存储和显示功能，免除了传统纤维丝的繁杂计算；
· 可以预设和选择大限额力度，精度1g，当达到预设值时，警示灯会亮；
· 实验简便安装在测试手柄上的探针对准实验对象，均匀施力，仪器能快速的显示结果并记录测试值；
· 数据可实时记录；
· 所有型号的电子测痛仪已在出厂前校准完毕，不再需要额外的校准设备；
大鼠小鼠足底触觉测试笼
大小鼠足底测试平台，也叫做老鼠足底触觉测试凿孔台，主要用于配合Von Frey电子测痛仪，对大鼠、小鼠进行足底触觉测试。
足底测试平台由三部分组成凿孔台、测试鼠笼和45°镜面（额外选配）
Supertips测试软丝
Supertips采用技术，有15根测试软丝组成。所有15根测试丝的直径的都在0.8mm，受测的接触面积具有高度的均一性。配合电子测痛仪使用，用于触觉阈值（Sensory Threshold）的测量。
Supertips测试丝采用特殊PP材质，受温度、湿度影响小，也有利于减少实验误差。
测试结果准确性高，可以直接用于评估痛阈，而不需复杂的计算。
部分参考文献
[HTML] An electronic pressure-meter nociception paw test for mice
TM Cunha, WA Verri Jr, GG Vivancos… - Brazilian Journal of …, 2004 - SciELO Brasil
... an inflammatory process and sensitized the paws of mice with different doses of carrageenin
ａnd prostaglandin E 2 (PGE 2 ... consisted of a hand-held force transducer fitted with a 0.5 mm
2 polypropylene tip (electronic von Frey anesthesiometer, IITC Inc., Life ...
[HTML] Pharmacological characterisation of a rat model of incisional pain
GT Whiteside, J Harrison, J Boulet… - British journal of …, 2004 - Wiley Online Library
... Pharma, Neuropharmacology, 6 Cedar Brook Drive, Cranbury, NJ 08512, USA E-mail: garth ... Issue
published online: 2 FEB 2009; Article first published online: 2 FEB 2009; ... previously described
in this model: tactile allodynia using an automated electronic von Frey (IITC, CA, USA ...
Pharmacological characterization of the chronic constriction injury model of neuropathic pain
J De Vry, E Kuhl, P Franken-Kunkel, G Eckel - European journal of …, 2004 - Elsevier
... 4 December 2003 Revised 1 March 2004 Accepted 25 March 2004 Available online 10 May
2004. Abstract. ... Mechanical allodynia was measured by means of a pressure transducer (electronic
von Frey Anaesthesiometer, IITC-Life Science Instruments, Woodlａnd Hills, CA). ...
Selective activation of cannabinoid CB2 receptors suppresses neuropathic nociception induced by treatment with the chemotherapeutic agent paclitaxel in rats
EJ Rahn, AM Zvonok, GA Thakur, AD Khanolkar… - … of Pharmacology and …, 2008 - ASPET
... E-mail: ahohmann{at}uga.edu. Next Section. Abstract. ... Mechanical withdrawal thresholds were
assessed using a digital electronic von Frey anesthesiometer (IITC model Alemo 2290-4; IITC
Life Sciences Inc., Woodlａnd Hills, CA) equipped with a rigid tip. ...
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, …
KJ Valenzano, L Tafesse, G Lee, JE Harrison… - …, 2005 - Elsevier
... 2004 Revised 26 November 2004 Accepted 10 December 2004 Available online 19 February ...
The marble-burying behavior model of anxiety (Njung'e ａnd Handley, 1990 ... noxious tactile stimulus
(VWT) were determined using an automated electronic von Frey apparatus (IITC ...
Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats
F Li, IG Obrosova, O Abatan, D Tian… - American Journal of …, 2005 - Am Physiological Soc
... Digital sensory NCV (SNCV) was recorded in the digital nerve to the second toe by stimulating
with a square ... by quantifying the withdrawal threshold of the hindpaw in response to mechanical
stimulation using a von Frey anesthesiometer (model 2290C; IITC Life Science ...
Activation of presynaptic NMDA receptors coupled to NaV1. 8-resistant sodium channel C-fibers causes retrograde mechanical nociceptor sensitization
CA Parada, GG Vivancos, CH Tambeli… - Proceedings of the …, 2003 - National Acad Sciences
... Intrathecal administration of prostaglandin E 2 (PGE 2 ), glutamate, and NMDA causes a bilateral
long-lasting mechanical paw hypernociception ... reflex with a hand-held force transducer adapted
with a 0.5-mm 2 polypropylene tip (electronic von Frey hair; IITC Life Science ...
The use of an electronic von Frey device for evaluation of sensory threshold in neurologically normal dogs and those with acute spinal cord injury
SA Moore, BF Hettlich, A Waln - The Veterinary Journal, 2013 - Elsevier
... Accepted 3 November 2012 Available online 13 December 2012. Abstract. The ...
examination. von Frey device. The electronic von Frey device (IITC Life Science)
consisted of a load cell, handle, recording device and tip (Fig. 1 ...
Reproducibility of electronic von frey and von frey monofilaments testing
B Tena, B Escobar, MJ Arguis, C Cantero… - The Clinical journal …, 2012 -
... Reprints: Beatriz Tena, MD, Hospital Clinic, c/Villarroel 170, 08036 Barcelona, Spain (e-mail:
btena@clinic.ub.es ... Pain threshold was subsequently determined using a pressure algometer,
the Electronic von Frey (Electronic Von Frey Anesthesiometer IITC). ...
TrkA and PKC-epsilon in thermal burn–induced mechanical hyperalgesia in the rat
GJ Summer, KA Puntillo, C Miaskowski, OA Dina… - The Journal of …, 2006 - Elsevier
... Received 5 December 2005 Revised 12 April 2006 Accepted 12 April 2006 Available online
6 December ... threshold in animals that underwent a plantar surface burn was assessed using an
electronic von Frey (EvF) model 1601CE anesthesiometer (IITC Life Science ...
，
