详情介绍：
美国AAPPTec公司
Apex 396平行合成仪
全自动多功能多肽合成仪
Apex 396平行合成仪，也称396多功能多肽合成仪是目前世界上平行多肽合成和单通道多肽合成仪的市场魁首。Apex 396平行合成仪是作为生产**研发库、扫描alanine scans、抗原表位定位和多肽平行试验库的理想仪器。合成规模从15毫克到2克。
高产量：
由于特氟龙反应器的设计，树脂停留在反应器底部，可以充分接触反应溶剂。基于这一点，树脂不会粘在反应器的边缘，因此Apex 396平行合成仪能够生产出更高产量的高纯度多肽。
高效率：
当维持一个惰性化境时，大气氮气辅助底部过滤能快速和地排清反应器，结果就是快速清空。这个处理，结合快速输送，减少多肽树脂分解应归于延长和酸的接触或者高效率的清洗树脂以防止杂质转移。
高质量：
这些特性与优点使得Apex 396平行合成仪成为全自动环境温度平行多肽合成仪的理想选择。
Apex 396平行合成仪是一个易于使用的自动化液体处理系统，能够胜任对液态、固相肽合成和有机合成反应。所有试剂、反应容器均在铝合金密封舱里，因此无需额外的通风橱设备。
Apex 396平行合成仪支持多达96个化合物可以在四氟乙烯块内同时合成，同时也可以在40孔、16孔和8孔模式中选择合成。
Apex 396平行合成仪在96孔反应模式下，合成时间平均为30摩尔肽，每个肽20分钟。依据化学合成过程，氨基酸循环累加时间范围从45分钟到1.5个小时。
Apex 396平行合成仪在96孔反应模式下，合成时间平均为30摩尔肽，每个肽20分钟。依据化学合成过程，氨基酸循环累加时间范围从45分钟到1.5个小时。
Apex 396平行合成仪同轴喷雾探头传输溶剂**度达到了0.5毫升。同轴探头有两个通道：用于溶剂和其他用于惰性气体（氮气或者氩气）。在溶剂送气过程中排出的溶剂替换为惰性气体在溶剂传输过程中，气体保持贯彻整个合成。探头还负责液体的检测，通过鉴定测量溶剂的电容率。这可确保探头进入液面一下的溶剂，探头接触减少可减少宝贵样品之间的交叉污染。
Apex 396平行合成仪反应容器通过正压的氮气压力被**干净，保持一种惰性环境并确保能有效去除容器底部的所溶剂和试剂。
Apex 396平行合成仪范围有四种模式：
Apex 396-SC: 单臂和经典反应器
Apex 396-DC: 双臂和经典反应器
Apex 396-DC-FW-S: 双臂系统，经典反应器，快洗功能和**臂单针探头
Apex 396-DC-FW-M: 双臂系统，经典反应器，快洗功能和**臂多针探头
Apex 396平行合成仪基于其可靠性、耐用性、易用性和高性能。高品质的纯钛可以容易和快速的合成。所有类型的肽和有机化学反应都可以在这个高度灵活的桌面单元操作。
主要特点：
• 多种肽合成执行液体和固相化学合成
• 1-96化合物可同时合成
• 多种氨基酸和反应容器配置
• 桌面多肽合成
• 全封闭罩，包含烟雾和有害气味
• 模式桌面试剂放置允许极大的灵活性
• 自动切割FMOC-化学
• 稀释器/注射器配药系统微升精度
• 双臂机器人可利用单或多探头在**臂上
主要技术参数：
• 可变规模合成
• 变速漩涡混合反应块，300-1200转/分钟
• 聚四氟乙烯不粘表面和惰性环境反应器
• 样品过滤聚四氟乙烯反应器熔块
• 隔垫反应孔维持压，防止交叉污染，并减少溶剂损失
• 铝制模式桌面允许灵活的试剂位置
• 多达6大部分外部溶剂线
• 350毫升和800毫升的试剂瓶
• 两个溶剂试剂稀释器在**个手臂上（在所有APEX型号）
• 用于来自稀释器的溶剂输送齿轮泵
• 准确的溶剂输送直到0.5升
• 同轴喷雾探头用于溶剂输送和液体检测
• 探头清洗站，以防止交叉污染
• 辅助氮正压力容器在不到1分钟排空
• 氮和溶剂的检测系统，以防止在试剂缺乏的情况下操作
• 快速请洗功能，在双臂的Apex型号，在96反应孔1-1.5分钟
• 直观的易于使用和编程简单的软件，指向和点击命令
主要选项：
可选配件：
聚四氟乙烯反应孔：96，40，16和8
• 树脂分配器：35毫克或70毫克可用
• 单体架：4x9架使用35毫升瓶，8X12架使用10毫升瓶，
2X5架使用25毫升瓶，5X6架使用125毫升瓶装。
可定制机架。
2X5架使用25毫升瓶，5X6架使用125毫升瓶装。
可定制机架。
• 酶标块96孔板的送样
• 样品的沉积、树脂切割，适用于96×4 ml样品瓶，40×6毫升小瓶，16×15毫升的小瓶和8×35毫升小瓶
灵活性：
* Apex 396平行合成仪既可以生产单个肽，也可以同时生产少量肽或者同时
生产多达96个肽。
* 双机器人臂精准的在任意两个点之间传输试剂。
* 密封罩内可以灵活地使用任何形状，尺寸或者放置容器
* Apex 396平行合成仪可以灵活的支持任何化学类型，包括预激活氨基酸
混合模式：
* Apex 396平行合成仪具备柔和但是高效的涡旋混合可以混合树脂和试剂
* Apex 396平行合成仪涡旋混合提供了高度的一致性和持续性，保障了高质量高纯肽和蛋白质的生产。
Apex 396平行合成仪是当今市场上上等的多肽合成仪。
Monomer Racks零件
Reagent Bottles反应瓶
Parts部件
关于美国AAPPTEC公司：
美国AAPPTEC公司，英文全称为Advanced Automated Peptide Protein Technologies公司,即美国*自动多肽蛋白技术公司成立于2005年3月，公司的前身是ACT（Advanced ChemTech）公司的仪器部。AAPPTEC公司购买了前ACT公司仪器的全部资产，包括生产线，砖利权以及在生产、和服务等方面的一家特权。AAPPTEC公司投入了充足的资源去提升和改进设备生产线，与此同时为药学界和生物领域提供了众多**性新产品。
AAPPTEC公司极其前身一直由Hossain Saneii博士来管理和运作整个公司，其总部设在美国肯塔吉州的路易斯维尔。近20年里，AAPPTEC公司在全自动多肽合成仪领域，针对不同的需求研发出数十种类型的仪器，加上长期实际应用验证的可靠性，这些仪器均可满足不同客户的不同需求，而且使用起来都相当便利，得到了用户的。AAPPTEC公司的多肽合成仪一定会满足您的需要，无论从仪器本身，到合成技术，到售后服务，我们在美国的工程师以及中国本土的高水平科学工作者也会一如既往地为您提供专业、周到的服务。
* 自然基因科技自2012年9月开始总代理美国AAPPTEC公司的产品。*
本产品提供1年全免费售后服务，包括产品介绍、送货、安装、调试、维修、技术培训服务等（与客户有特殊约定的按照约定执行）。
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附录：参考文献---谁在使用这台仪器？
Apex 396平行合成仪文献
Parekh, SH; Chatterjee, K; Lin-Gibson, S; Moore, NM; Cicerone, MT; Young, MF; Simon, CG., Jr.
“Modulus-Driven Differentiation of Marrow StromaCells in 3D Scaffolds that is Independent of
Myosin-Based CytoskeletaTension” Biomaterials, 2011, 32, 2256-2264.
Patel, D; Menon, R; Taite, LJ. “Self-Assembly of Elastin-Based Peptides into the ECM: the
Importance of Integrins and the Elastin Binding Protein in Elastic Fiber Assembly”
Biomacromolecules, 2011, 12, 432-440.
Yu, Z; Zhao, W; Liu, J; Lu, J; Chen, F. “QIGLF, a NoveAngiotensin I-Converting Enzyme-
Inhibitory Peptide From Egg White Protein” J. Sci. Food Agricul., 2011, 91, 921-926.
Anderson, JM; Vines, JB; Patterson, JL; Chen, H; Javed, A; Jun, H-W. “Osteogenic Differentiation
of Human MesenchymaStem Cells Synergystically Enhanced by Biomimetic Peptide
Amphiphiles Combined with Conditioned Medium” Acta Biomater., 2011, 7, 675-682.
Saik, JE; Gould, DJ; Watkins, EM; Dickinson, ME; West, JL. “Covalently Immobilized Platelet-
Derived Growth Factor BB Promotes Angiogenesis in Biomimetic Poly(Ethylene Glycol)
Hydrogels” Acta Biomater., 2011, 7, 133-143.
Aranda, F; Llopiz, D; Díaz-Valdés, N; Riezu-Boj, JI; Bezunartea, J; Ruiz, M; Martínez, M;
Durantez, M; Mansilla, C; Prieto, J; Lasarte, JJ; Borrás-Cuesta, F; Sarobe, P, “Adjuvant
Combination and Antigen Targeting as a Strategy to Induce Polyfunctionaａnd High-Avidity TCell
Responses against Poorly Immunogenic Tumors” Cancer Res., 2011, 71, 3214 - 3224.
Lu, C; Williams, A; Chan, S; McFarland, M; Gomez-Lemus, J; Chin, J; Izawa, J; Luyt, L; Lewis, J,
“2317 Ghrelin Receptor Labling as a NoveImaging Marker for Prostatic Neoplasms” The Journal
of Urology, 2011, 185, Supplement 1, e92.
Moore, NM; Lin, NJ; Gallant, ND; Becker, ML, “Synergistic enhancement of human bone marrow
stromacelproliferation and osteogenic differentiation on BMP-2-derived and RGD peptide
concentration gradients” Acta Biomaterialia, 2011, 7, 2091-2100.
Fridkin, G; Maina, T; Nock, BA; Blat, D; Lev-Goldman, V; Scolnik, Y; Kapitkovski, A; Vachutinsky,
Y; Shechter, Y; Levy, Y, “Intramolecular azo-bridge as a cystine disulfide bond surrogate:
Somatostatin-14 and brain natriuretic peptide (BNP) analogs” Bioorganic & MedicinaChemistry,
2011, 19, 798-806.
Andukuri, A; Kushwaha, M; Tambralli, A; Anderson, JM; Dean, DR; Berry, JL; Sohn, YD; Yoon, YS;
Brott, BC; Jun, H-W, “A hybrid biomimetic nanomatrix composed of electrospun
polycaprolactone and bioactive peptide amphiphiles for cardiovascular implants” Acta
Biomaterialia, 2011, 7, 225-233.
Anderson, JM; Vines, JB; Patterson, JL; Chen, H; Javed, A; Jun, H-W, “Osteogenic differentiation
of human mesenchymastem cells synergistically enhanced by biomimetic peptide amphiphiles
combined with conditioned medium” Acta Biomaterialia, 2011, 7, 675-68.
Wang, Y; Bakota, E; Chang, BHJ; Entman, M; Hartgerink, JD; Danesh, FR, “Peptide Nanofibers
Preconditioned with Stem CelSecretome Are Renoprotective” J. Am. Soc. Nephrol., 2011, 22,
704 - 717.
O’Leary, LER; Fallas, JA Hartgerink, JD, “Positive and Negative Design Leads to Compositional
Controin AAB Collagen Heterotrimers” J. Am. Chem. Soc., 2011, 133, 5432–5443.
Guilherme, L; Alba, MP; Ferreira, FM; Oshiro, SE; Higa, F; Patarroyo, ME; Kalil, J, “Anti-Group A
StreptococcaVaccine Epitope: Structure, Stability, and Its Ability to Interact With HLA Class II
Molecules” J. Biol. Chem., 2011, 286, 6989-6998.
Saik, JE; Gould, DJ; Watkins, EM; Dickinson, ME; West, JL, “Covalently immobilized plateletderived
growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels”
Acta Biomaterialia, 2011, 7, 133-143.
Bradshaw, RT; Patel, BH; Tate, EW; Leatherbarrow, RJ; Gould, IR, “Comparing experimentaand
computationaalanine scanning techniques for probing a prototypicaprotein–protein interaction”
Protein Eng. Des. Sel., 2011, 24, 197-207.
Parekh, SH; Chatterjee, K; Lin-Gibson, S; Moore, NM; Cicerone, MT; Young, MF; Simon, CG, Jr.,
“Modulus-driven differentiation of marrow stromacells in 3D scaffolds that is independent of
myosin-based cytoskeletatension” Biomaterials, 2011, 32, 2256-2264.
Ponnaluri, VKC; Vavilala, DT; Mukherji, M, “Studies on substrate specificity of Jmjd2a-c histone
demethylases” Biochemicaａnd BiophysicaResearch Communications, 2011, 405, 588-592.
Wang, H; Xu, K; Liu, L; Tan, JPK; Chen, Y; Li, Y; Fan, W; Wei, Z; Sheng, J; Yang, Y-Y; Li,L. “The
Efficacy of Self-Assembled Cationic AntimicrobiaPeptide Nanoparticles Against Cryptococcus
neoformans for the Treatment of Meningitis” Biomaterials, 2, 31, 2874-2881.
Moore, NM; Lin, NJ; Gallant, ND; Becker, ML. “The Use of Immobilized Osteogenic Growth
Peptide on Gradient Substrates Synthesized Via Click Chemistry to Enhance MC3T3-E1
Osteoblast Proliferation” Biomaterials, 2,
Ghadial, JE; Cohen, BE; Stevens, MM. “Protein Kinase-Actuated Resonance Energy Transfer in
Quantum Dot-Peptide Conjugates” ACS Nano, 2, 4, 4915-9.
Brims, DR; Qian, J; Jarchum, I; Mikesh, L; Palmieri, E; Ramagopal, UA; Malashkevich, VN;
Chaparro, RJ; Lund, T; Hattori, M; Shabanowitz, J; Hunt, DF; Nathenson, SG; Almo, SC;
DiLorenzo, TP, “Predominant occupation of the class I MHC molecule H-2Kwm7 with a single
self-peptide suggests a mechanism for its diabetes-protective effect” Int. Immunol., 2; 22,
191-203.
Amadi, GA; Cho, C-F; Lewis, JD; Luyt, LG. “A Fast, Reproducible and Low-Cost Method For
Sequence Deconvolution of ‘On-Bead’ Peptides Via ‘On-Target’ Maldi-TOF/TOF Mass
Spectrometry” J. Mass Spect., 2, 45, 241-51.
Godugu, B; Neta, P; Simón-Manso, Y; Stein, SE. “Effect of N-TerminaGlutamic Acid and
Glutamine on Fragmentation of Peptide Ions” J. Am. Soc. Mass Spect., 2, 1169-1176.
Rosales, AM; Murnen, HK; Zuckermann, RN; Segalman, RA. “Controof Crystallization and
Melting Behavior in Sequence Specific Polypeptoids” Macromolecules, 2, 43, 5627-36.
Murnen, HK; Rosales, AM; Jaworski, JN; Segalman, RA; Zuckermann, RN. “HeirachicaSelf-
Assembly of a Biomimetic Diblock Copolypeptoid into HomochiraSuperhelices” J. Am. Chem.
Soc., 2, 132, 16112-9.
Azad, BB; Rota, VA; Breadner, D; Dhanvantari, S; Luyt, LG. “Design, Synthesis and in vitro
Characterization of Glucagon-Like Peptide-1 Derivatives for Pancratic Beta CelImaging by
SPECT” Bioorg. Med. Chem., 2, 18, 1265-1272.
Feliu, L; Oliveras, G; Cirac, AD; Besalú, E; Rosés, C; Colomer, R; Bardají, E; Planas, M; Puig, T,
“Antimicrobiacyclic decapeptides with anticancer activity” Peptides, 2, 31, 2017-202.
Guzman, E; Taylor, G; Charleston, B; Ellis, SA, “Induction of a Cross-Reactive CD8+ T Cell
Response following Foot-and-Mouth Disease Virus Vaccination” J. Virol., 2, 84, 12375-12384.
Galler, KM; Aulisa, L; Regan, KR; D’Souza, RN; Hartgerink, JD, “Self-Assembling Multidomain
Peptide Hydrogels: Designed Susceptibility to Enzymatic Cleavage Allows Enhanced Cell
Migration and Spreading” J. Am. Chem. Soc., 2, 132, 3217–3223.
Kushwaha, M; Anderson, JM; Bosworth, CA; Andukuri, A; Minor, WP; Lancaster, JR, Jr.;
Anderson, PG; Brott, BC; Jun, H-W, “A nitric oxide releasing, self assembled peptide amphiphile
matrix that mimics native endothelium for coating implantable cardiovascular devices”
Biomaterials, 2, 31, 1502-1508.
Weiger, MC; Park, JJ; Roy, MD; Stafford, CM; Karim, A; Becker, ML, “Quantification of the
binding affinity of a specific hydroxyapatite binding peptide” Biomaterials, 2, 31, 2955-2963.
Choi, Y-S; Lee, JY; Suh, JS; Kwon, Y-M; Lee, S-J; Chung, J-K; Lee, D-S; Yang, VC; Chung, C-P;
Park, Y-J, “The systemic delivery of siRNAs by a celpenetrating peptide, low molecular weight
protamine” Biomaterials, 2, 31, 1429-1443.
Andukuri, A; Minor, WP; Kushwaha, M; Anderson, JM; Jun, H-W, “Effect of endothelium
mimicking self-assembled nanomatrices on celadhesion and spreading of human endothelial
cells and smooth muscle cells” Nanomedicine: Nanotechnology, Biology and Medicine, 2, 6,
289-297.
Rubin, N; Perugia, E; Wolf, SG; Klein, E; Fridkin, M; Addadi, L, “Relation between Serum Amyloid
A Truncated Peptides and Their Suprastructure Chirality” J. Am. Chem. Soc., 2, 132, 4242–
4248.
So, S; Peeva, LG; Tate, EW; Leatherbarrow, RJ; Livingston, AG, “Organic Solvent Nanofiltration:
A New Paradigm in Peptide Synthesis” Org. Process Res. Dev., 2, 14, 1313–1325.
Baumhover, NJ; Anderson, K; Fernandez, CA; Rice, KG, “Synthesis and In Vitro Testing of New
Potent Polyacridine−Melittin Gene Delivery Peptides” Bioconjugate Chem., 2, 21, 74–83.
Godugu, B; Neta, P; Simón-Manso, Y; Stein, SE, “Effect of N-TerminaGlutamic Acid and
Glutamine on Fragmentation of Peptide Ions” Journaof the American Society for Mass
Spectrometry, 2, 21, 1169-1176.
Ghadiali, JE; Cohen, BE; Stevens, MM, “Protein Kinase-Actuated Resonance Energy Transfer in
Quantum Dot−Peptide Conjugates” ACS Nano, 2, 4, 4915–4919.
Moore, NM; Lin, NJ; Gallant, ND; Becker, ML, “The use of immobilized osteogenic growth peptide
on gradient substrates synthesized via click chemistry to enhance MC3T3-E1 osteoblast
proliferation” Biomaterials, 2, 31, 1604-1611.
Choi, YJ; Lee, JY; Park, JH; Park, JB; Suh, JS; Choi, YS; Lee, SJ; Chung, C-P; Park, YJ, “The
identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role
on osteogenesis” Biomaterials, 2, 31, 7226-7238.
Anderson, K; Fernandez, C; Rice, KG, “N-Glycan Targeted Gene Delivery to the Dendritic Cell
SIGN Receptor” Bioconjugate Chem., 2, 21, 1479–1485.
Fernandez, CA; Baumhover, NJ; Anderson, K; Rice, KG, “Discovery of Metabolically Stabilized
Electronegative Polyacridine-PEG Peptide DNA Open Polyplexes” Bioconjugate Chem., 2,
21, 723–730.
Tait, S; Dutta, K; Cowburn, D; Warwicker, J; Doig, AJ; McCarthy, JEG, “Locacontroof a
disorder–order transition in 4E-BP1 underpins regulation of translation via eIF4E” PNAS, 2,
107, 17627-17632.
He, J; Yarbrough, DK; Kreth, J; Anderson, MH, Shi, W; Eckert, R, “Systematic Approach to
Optimizing Specifically Targeted AntimicrobiaPeptides against Streptococcus mutans”
Antimicrob. Agents Chemother., 2, 54, 2143-2151.
Wang, H; Xu, K; Liu, L; Tan, JPK; Chen, Y; Li, Y; Fan, W; Wei, Z; Sheng, J; Yang, Y-Y; Li, L, “The
efficacy of self-assembled cationic antimicrobiapeptide nanoparticles against Cryptococcus
neoformans for the treatment of meningitis” Biomaterials, 2, 31, 2874-2881.
Azad, BB; Rota, VA; Breadner, B; Dhanvantari, S; Luyt, LG, “Design, synthesis and in vitro
characterization of Glucagon-Like Peptide-1 derivatives for pancreatic beta celimaging by
SPECT” Bioorganic & MedicinaChemistry, 2, 18, 1265-1272.
Guilherme, L; Postol, E; Freschi de Barros, S; Higa, F; Alencar, R; Lastre, M; Zayas, C; Puschel,
CR; Silva, WR; Sa-Rocha, LC; Sa-Rocha, VM; Pérez, O; Kalil, J. “A vaccine against S. pyogenes:
Design and experimentaimmune response” Methods, 2009, 49, 316-321.
Duryee, MJ; Bevins, RA; Reichel, CM; Murray, JE; Dong, Y; Thiele, GM; Sanderson, SD,
“Immune responses to methamphetamine by active immunization with peptide-based, molecular
adjuvant-containing vaccines” Vaccine, 2009, 27, 2981-2988.
Fallas, JA; Gauba, V; Hartgerink, JD, “Solution Structure of an ABC Collagen Heterotrimer
Reveals a Single-register Helix Stabilized by Electrostatic Interactions” J. Biol. Chem., 2009, 284,
26851-26859.
Rosita, D; DeWit, MA; Luyt, LG, “Fluorine and Rhenium Substituted Ghrelin Analogues as
PotentiaImaging Probes for the Growth Hormone Secretagogue Receptor” J. Med. Chem., 2009,
52, 2196–2203.
Lee, J-Y; Choo, J-E; Choi, Y-S; Suh, J-S; Lee, S-J; Chung, C-P; Park, Y-J, “Osteoblastic
differentiation of human bone marrow stromacells in self-assembled BMP-2 receptor-binding
peptide-amphiphiles” Biomaterials, 2009, 30, 3532-3541.
Kim, J-K; Anderson, J; Jun, H-W; Repka, MA; Jo, S, “Self-Assembling Peptide Amphiphile-Based
Nanofiber Gefor Bioresponsive Cisplatin Delivery” Mol. Pharmaceutics, 2009, 6, 978–985.
Lopes, LB; Flynn, C; Komalavilas, P; Panitch, A; Brophy, CM; Seal, BL, “Inhibition of HSP27
phosphorylation by a cell-permeant MAPKAP Kinase 2 inhibitor” Biochemicaａnd Biophysical
Research Communications, 2009, 382, 535-539.
LeBeau, AM; Banerjee, SR; Pomper, MG; Mease, RC; Denmeade, SR, “Optimization of peptidebased
inhibitors of prostate-specific antigen (PSA) as targeted imaging agents for prostate
cancer” Bioorganic & MedicinaChemistry, 2009, 17, 4888-489.
Tam, RY; Rowley, CN; Petrov, I; Zhang, T; Afagh, NA; Woo, TK; Ben, RN, “Solution
Conformation of C-Linked Antifreeze Glycoprotein Analogues and Modulation of Ice
Recrystallization” J. Am. Chem. Soc., 2009, 131, 15745–15753.
Bakota, EL; Aulisa, L; Tsyboulski, DA; R. Weisman, RB; Hartgerink, JD, “Multidomain Peptides as
Single-Walled Carbon Nanotube Surfactants in CelCulture” Biomacromolecules, 2009, 10,
2201–2206.
Duryee, MJ; Bevins, RA; Reichel, CM; Murray, JE, Dong, Y; Thiele, GM; Sanderson SD. “Immune
Responses to Methamphetamine by Active Immunization with Peptide-Based, Molecular
Adjuvant-Containing Vaccines” Vaccine, 2009, 27, 2981-2988.
LeBeau, AM; Banerjee, SR; Pomper, MG; Mease, RC; Denmeade, SR. “Optimization of Peptide-
Based Inhibitors of Prostate-Specific Antigen (PSA) as Targeted Imaging Agents for Prostate
Cancer” Bioorg. Med. Chem. Letters, 2009, 17, 4888-4893.
LeBeau, AM; Brennen, WN; Aggarwal, S; Denmeade, SR, “Targeting the cancer stroma with a
fibroblast activation protein-activated promelittin protoxin” Mol. Cancer Ther. 2009, 8, 1378-1386.
Lopes, LB; Flynn, C; Komalavilas, P; Panitch, A; Brophy, CM; Seal, BL. “Inhibition of HSP27
Phosphorylation by a Cell-Permeant MAPKAP Kinase 2 Inhibitor” Biochem. Biophys. Res.
Commun., 2009, 382, 535-539.
Phillips, JA; Morgan, EL; Dong, Y; Cole, GT; McMahan, C; Hung C-Y; Sanderson, SD. “Single-
Step Conjugation of Bioactive Peptides to Proteins via a Self-Contained SuccinimidyBis-
Arylhydrazone” Bioconjugate Chem., 2009, 20, 1950–1957.
Wang, D; Fang, S; Wohlhueter, RM. “N-TerminaDerivatization of Peptides with Isothiocyanate
Analogues Promoting Edman-Type Cleavage and Enhancing Sensitivity in Electrospray
Ionization Tandem Mass Spectrometry Analysis” Anal. Chem., 2009, 81, 1893–1900.
Ueda, T; Tomita, K; Notsu, Y; Ito, T; Fumoto, M; Takakura, T; Nagatome, H; Takimoto, A; Mihara,
S-I; Togame, H; Kawamoto, K; Iwasaki, T; Asakura, K; Oshima, T; Hanasaki, K, Nishimura S-I;
Kondo, H. “Chemoenzymatic Synthesis of Glycosylated Glucagon-like Peptide 1: Effect of
Glycosylation on Proteolytic Resistance and in Vivo Blood Glucose-Lowering Activity” J. Am.
Chem. Soc., 2009, 131, 6237–6245.
LeBeau, AM; Singh, P; Isaacs JT; Denmeade, SR. “Prostate-Specific Antigen Is a “Chymotrypsinlike”
Serine Protease with Unique P1 Substrate Specificity” Biochemistry, 2009, 48, 3490–3496.
Seow, WY; Yang, Y-Y. “A Class of Cationic Triblock Amphiphilic Oligopeptides as Efficient Gene-
Delivery Vectors” Advanced Mater., 2009, 21, 86-90.
Lui, S; Zhou, L; Chen, L; Dastidar, SG; Verma, C; Ll, J; Tan, D; Beuerman, R. “Effect of Structural
Parameters of Peptides on Dimer Formation and Highly Oxidized Side Products in the Oxidation
of Thiols of Linear Analogs of Human β-Defensin 3 by DMSO” J. Pept. Sci. 2009, 15, 95-106.
Kiviranta, PH; Suuronen, T; Walln, EAA; Leppnen, J; Tervonen, J; Kyrylenko, S; Salminen, A;
Poso, A; Jarho, EM, “N-Thioactyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and
SIRT2 Inhibitors” J. Med. Chem., 2009, 52, 2153–2156
Román-Hernández, G; Grant, RA, Sauer, RT; Baker, TA, “Molecular basis of substrate selection
by the N-end rule adaptor protein ClpS” PNAS, 2009, 106, 8888 - 8893.
Ivanova, GD; Arzumanov, A; Abes, R; Yin, H; Wood, MJA; Lebleu, B; Gait, MJ, “Improved cellpenetrating
peptide–PNA conjugates for splicing redirection in HeLa cells and exon skipping in
mdx mouse muscle” Nucleic Acids Res., 2008, 36, 6418-6428.
Wang, KH; Oakes, ESC; Sauer, RT; Baker, TA, “Tuning the Strength of a BacteriaN-end Rule
Degradation Signal” J. Biol. Chem., 2008, 283, 24600-24607.
Garcia, TCM; Fonseca, CT; Pacifico, LGG; Durães, FdV; Antônio F; Marinho, V; Penido, MLO;
Caliari, MV; de Melo, AL; Pinto, HA; Barsante, MM; Cunha-Neto, E; Oliveira, SC, “Peptides
containing T celepitopes, derived from Sm14, but not from paramyosin, induce a Th1 type of
immune response, reduction in liver pathology and partiaprotection against Schistosoma
mansoni infection in mice” Acta Tropica, 2008, 106, 162-167.
Romanini, DW; Francis, MB, “Attachment of Peptide Building Blocks to Proteins Through
Tyrosine Bioconjugation” Bioconjugate Chem., 2008, 19, 153–157.
Wei, F; Zhang, D; Halas, NJ; Hartgerink, JD, “Aromatic Amino Acids Providing Characteristic
Motifs in the Raman and SERS Spectroscopy of Peptides” J. Phys. Chem. B, 2008, 112, 9158–
9164.
Martin, ME; Rice, KG, “A NoveClass of Intrinsic Proteasome Inhibitory Gene Transfer Peptides”
Bioconjugate Chem., 2008, 19, 370–376.
Tsyboulski, DA; Bakota, EL; Witus, LS; Rocha, J-DR; Hartgerink, JD; Weisman, RB, “Self-
Assembling Peptide Coatings Designed for Highly Luminescent Suspension of Single-Walled
Carbon Nanotubes” J. Am. Chem. Soc., 2008, 130, 17134–17140.
Blat, D; Weiner, L; Youdim, MBH; Fridkin, M, “A NoveIron-Chelating Derivative of the
Neuroprotective Peptide NAPVSIPQ Shows Superior Antioxidant and Antineurodegenerative
Capabilities” J. Med. Chem., 2008, 51, 126–134.
Fournier, F; Gardner, EM; Guo, R; Donaldson, PM; Barter, LMC; Palmer, DJ; Barnett, CJ;
Willison, KR; Gould, IR; Klug, DR, “Opticafingerprinting of peptides using two-dimensional
infrared spectroscopy: Proof of principle” AnalyticaBiochemistry, 2008, 374, 358-365.
Han, X; Shigaki, S; Yamaji, T; Yamanouchi, G; Mori, T; Niidome, T; Katayama, Y, “A quantitative
peptide array for evaluation of protein kinase activity” AnalyticaBiochemistry, 2008, 372, 106-
115.
Torres, O; Yüksel, D; Bernardina, M; Kumar, K; Bong, D. “Peptide Tertiary Structure Nucleation
by Side-Chain Crosslinking with MetaComplexation and Double “Click” Cycloaddition”
ChemBioChem. 2008, 9, 1701-1705.
Yu, MM; Wang, RF; Yan, P; Zhang, CL; Liu, M; Cui, YG. “Design, Synthesis and Iodination of an
Arg-Arg-Leu Peptide for PotentiaUse as an Imaging Agent for Human Prostate Carcenoma” J.
Labelled Comp. Radiopharm., 2008, 51, 374-378.
Liu, S; Zhou, L;, Li, J; Suresh, A; Verma, C; Foo, YH; Yap, EPH; Tan, DTH; Beuerman, RW.
“Linear Analogs of Human β-Defensin 3: Concepts for Design of AntimicrobiaPeptides with
Reduced Cytotoxicity to Mammalian Cells” ChemBioChem. 2008, 9, 964-973.
Peng, W; Wang, HY; Miyahara, Y; Peng, G; Wang, R-F, “Tumor-Associated Galectin-3 Modulates
the Function of Tumor-Reactive T Cells” Cancer Res. 2008, 68, 7228-7236.
Greidinger, EL; Zang, YJ; Jaimes, K; Martinez, L; Nassiri, M; Hoffman, RW, “CD4+ T Cells Target
Epitopes Residing within the RNA-Binding Domain of the U1-70-kDa SmalNuclear
Ribonucleoprotein Autoantigen and Have Restricted TCR Diversity in an HLA-DR4-Transgenic
Murine Modeof Mixed Connective Tissue Disease” J. Immunol. 2008, 180, 8444-8454.
Jahn-Schmid, B; Sirven, P; Leb, V; Pickl, WF; Fischer, GF; Gadermair, G; Egger, M; Ebner, C;
Ferreire, F: Maillére, B; Bohle, B. “Characterization of HLA Class II/Peptide-TCR Interactions of
the Immunodominant T CelEpitope in Art v 1, the Major Mugwort Pollen Allergen” J. Immunol.
2008, 181, 3636-42.
Bernardina, M; Kumar, K; Bong, D; “Peptide Tertiary Structure by Side-Chain Crosslinking with
MetaComplexation and Double “Click” Cycloaddition” ChemBioChem, 2008, 9, 1701-5.
Shu, JY; Tan, C; DeGrado, WF; Xu, T. “New Design of Helix Bundle Peptide−Polymer
Conjugates” Biomacromolecules, 2008, 9, 2111–2117.
Gong, Y; Ma, M; Luo, Y; Bong, D, “FunctionaDeterminants of a Synthetic Vesicle Fusion
System” J. Am. Chem. Soc., 2008, 130, 6196–6205.
Edwards, WB; Xu, B; Akers, W; Cheney, PP; Liang, K; Rogers, BE; Anderson, CJ; Achilefu, S,
“Agonist−Antagonist Dilemma in Molecular Imaging: Evaluation of a Monomolecular Multimodal
Imaging Agent for the Somatostatin Receptor” Bioconjugate Chem., 2008, 19, 192–200.
Wang, KH; Roman-Hernandez, G; Grant, RA; Sauer, RT; Baker, TA, “The Molecular Basis of NEnd
Rule Recognition” Molecular Cell, 2008, 32, 406-414.
Mäkelä, AR; Närvänen, A; Oker-Blom, C, “Peptide-mediated interference with baculovirus
transduction” Journaof Biotechnology, 2008, 134, 20-32.
Fabani MM; Gait, MJ, “miR-122 targeting with LNA/2'-O-methyoligonucleotide mixmers, peptide
nucleic acids (PNA), and PNA–peptide conjugates” RNA, 2008, 14, 336-346.
Lopes, LB; Furnish, E; Komalavilas, P; Seal, BL; Panitch, A; Vitória, M; Bentley, LB; Brophy, CM,
“Enhanced skin penetration of P20 phosphopeptide using protein transduction domains”
European Journaof Pharmaceutics and Biopharmaceutics, 2008, 68, 441-445.
Neta, P; Pu, Q-L; Yang, X; Stein, SE, “Consecutive neutralosses of H2O and C2H4O from NTerminal
Thr–Thr and Thr–Ser in collision-induced dissociation of protonated peptides: Position
dependent water loss from single Thr or Ser” InternationaJournaof Mass Spectrometry, 2007,
267, 295-301.
Hoyer, KM; Mahlert, C; Marahiel, MA, “The Iterative Gramicidin S Thioesterase Catalyzes Peptide
Ligation and Cyclization” Chemistry & Biology, 2007, 14, 13-22.
McAuley, JL; Hornung, F; Boyd, KL; Smith, AM; McKeon, R; Bennink, J; Yewdell, JW; McCullers,
JA, “Expression of the 1918 Influenza A Virus PB1-F2 Enhances the Pathogenesis of Viraand
Secondary BacteriaPneumonia” CelHost & Microbe, 2007, 2, 240-249.
Lee, J-Y; Choo, J-E; Choi, Y-S; Park, J-B; Min, D-S; Lee, S-J; Rhyu, HK, Jo, I-H; Chung, C-P;
Park, Y-J, “Assembly of collagen-binding peptide with collagen as a bioactive scaffold for
osteogenesis in vitro and in vivo” Biomaterials, 2007, 28, 4257-4267.
Frahm, N; Kaufmann, DE; Yusim, K; Muldoon, M; Kesmir, C; Linde, CH; Fischer, W; Allen, TM;
Li, B; McMahon, BH; Faircloth, KL; Hewitt, HS; Mackey, EW; Miura, T; Khatri, A; Wolinsky, S;
McMichael, A; Funkhouser, RK; Walker, BD; Brander, C; Korber, BT, “Increased Sequence
Chen, C; Kim, J; Liu, D; Rettig, GR; McAnuff, MA; Martin, ME; Rice, KG, “Synthetic PEGylated
Glycoproteins and Their Utility in Gene Delivery” Bioconjugate Chem., 2007, 18 (2), pp 371–378.
Diversity Coverage Improves Detection of HIV-Specific T CelResponses” J. Immunol., 2007,
179, 6638-6650.
Leavy, TM; Bertozzi, CR, “A high-throughput assay for O-GlcNAc transferase detects primary
sequence preferences in peptide substrates”, Bioorganic & MedicinaChemistry Letters, 2007,
17, 3851-3854.
Penna, G; Amuchastegui, S; Cossetti, C; Aquilano, F; Mariani, R; Giarratana, N; De Carli, E;
Fibbi, B; Adorini, L, ”Spontaneous and Prostatic Steroid Binding Protein Peptide-Induced
Autoimmune Prostatitis in the Nonobese Diabetic Mouse” J. Immunol., 2007, 179, 1559-1567.
Abes, S; Turner, JJ; Ivanova, GD; Owen, D; Williams, D; Arzumanov, A; Clair, P; Gait, MJ; and
Lebleu, B, “Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide”
Nucleic Acids Res., 2007, 35, 4495-4502.
Samel, SA; Schoenafinger, G; Knappe, TA; Marahiel, MA; Essen, L-O, “Structuraａnd Functional
Insights into a Peptide Bond-Forming Bidomain from a NonribosomaPeptide Synthetase”
Structure, 2007, 15, 781-79.
Sweeney, TR; Roqué-Rosell, N; Birtley, JR; Leatherbarrow, RJ; Curry, S. “Structuraand
Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the ß-
Ribbon in Proteolysis”, J. Virol., 2007, 81, 115-124.
Miller, SA; Tollefson, S; Crowe, JE, Jr.; Williams, JV; Wright, DW, “Examination of a Fusogenic
Hexameric Core from Human Metapneumovirus and Identification of a Potent Synthetic Peptide
Inhibitor from the Heptad Repeat 1 Region”, J. Virol., 2007, 81, 141-149.
Dong, H; Hartgerink, JD, “Role of Hydrophobic Clusters in the Stability of a-HelicaCoiled Coils
and Their Conversion to Amyloid-like ß-Sheets”, Biomacromolecules, 2007, 8, 617-623.
Neta, P; Pu, Q-L; Yang, X; Stein, SE. “Consecutive NeutraLosses of H2O and C2H4O from NTerminal
Thr-Thr and Thr-Ser in Collision-Induced Dissociation of Protonated Peptides: Position
Dependent Water Loss from Single Thr or Ser” Int. J. Mass Spec., 2007, 267, 295-301.
Lee, S-H; Moon, JJ; Miller, JS; West, JL. “Poly(Ethylene Glycol) Hydrogels Conjugated with a
Collagenase-Sensitive Fluorogenic Substrateto Visualize Collagenase Activity During Three-
DimensionaCelMigration” Biomaterials, 2007, 28, 3163-3170.
Jaulent, AM; Fahy, AS; Knox, SR; Birtley, JR; Roqué-Rosell, N; Curry, S; Leatherbarrow, RJ, “A
continuous assay for foot-and-mouth disease virus 3C protease activity” AnalyticaBiochemistry,
2007, 368, 130-137.
He, J; Eckert, R; Pharm, T; Simanian, MD; Hu, C; Yarbrough, DK; Qi, F; Anderson, MH; Shi, W,
“NoveSynthetic AntimicrobiaPeptides against Streptococcus mutans” Antimicrob. Agents
Chemother., 2007, 51, 1351-1358.
Lee, S; Miller, SA; Wright, DW; Rock, MT; Crowe, JE, Jr., “Tissue-Specific Regulation of CD8+ TLymphocyte
Immunodominance in Respiratory SyncytiaVirus Infection” J. Virol., 2007, 81, 2349-
2358.
Nuti, F; Paolini, I; Cardona, F; Chelli, M; Lolli, F; Brandi, A; Goti, A; Rovero, P; Papini, AM,
“Fmoc-protected iminosugar modified asparagine derivatives as building blocks for
glycomimetics-containing peptides” Bioorganic & MedicinaChemistry, 2007, 15, 3965-397.
Lee, J-Y; Choo, J-E; Park, H-J; Park, J-B; Lee, S-C; Jo, I; Lee, S-J; Chung, C-P; Park, Y-J,
“Injectable gewith synthetic collagen-binding peptide for enhanced osteogenesis in vitro and in
vivo” Biochemicaａnd BiophysicaResearch Communications, 2007, 357, 68-74.
Sweeney, TR: Roqué-Rosell, N; Birtley, JR, Leatherbarrow, RJ; Curry, S, “Structuraand
Mutagenic Analysis of Foot-and-Mouth Disease Virus 3C Protease Reveals the Role of the ß-
Ribbon in Proteolysis” J. Virol., 2007, 81, 115-124.
Miller, SA; Tollefson, S; Crowe, JE, Jr.; Williams, JV; Wright, DW, “Examination of a Fusogenic
Hexameric Core from Human Metapneumovirus and Identification of a Potent Synthetic Peptide
Inhibitor from the Heptad Repeat 1 Region” J. Virol., 2007, 81, 141-149.
Lee, S-H; Moon, JJ; Miller, JS; West, JL, “Poly(ethylene glycol) hydrogels conjugated with a
collagenase-sensitive fluorogenic substrate to visualize collagenase activity during threedimensional
celmigration” Biomaterials, 2007, 28, 3163-3170.
Sprague, JE; Li, WP; Liang, K; Achilefu, S; Anderson, CJ, “In vitro and in vivo investigation of
matrix metalloproteinase expression in metastatic tumor models” Nuclear Medicine and Biology,
2006, 33, 227-237.
Penna, G; Amuchastegui, S; Cossetti, C; Aquilano, F; Mariani, R; Sanvito, F; Doglioni, C; Adorini,
L, “Treatment of ExperimentaAutoimmune Prostatitis in Nonobese Diabetic Mice by the Vitamin
D Receptor Agonist Elocalcitol” J. Immunol., 2006, 177, 8504-8511.
Zarling, AL; Polefrone, JM; Evans, AM; Mikesh, LM; Shabanowitz, J; Lewis, ST; Engelhard, VH;
Hunt, DF, “From the Cover: Identification of class I MHC-associated phosphopeptides as targets
for cancer immunotherapy” PNAS, 2006, 103, 14889-14894.
Bloch, S; Xu, B; Ye, Y; Liang, K; Nikiforovich, GV; Achilefu, S, “Targeting Beta-3 Integrin Using a
Linear Hexapeptide Labeled with a Near-Infrared Fluorescent Molecular Probe” Mol.
Pharmaceutics, 2006, 3, 539–549.
Hekim, C; Leinonen, J, Närvänen, A; Koistinen, H; Zhu, L; Koivunen, E; Väisänen, V; Stenman,UH,
“NovePeptide Inhibitors of Human Kallikrein 2” J. Biol. Chem., 2006, 281, 12555-12560.
Wagner, B; Schumann, D; Linne, U; Koert, U; Marahiel, MA, “RationaDesign of Bacitracin A
Derivatives by Incorporating NaturaProduct Derived Heterocycles” J. Am. Chem. Soc., 2006,
128, 10513–10520.
Abes, S; Williams, D; Prevot, P; Thierry, A; Gait, MJ; Lebleu, B, “Endosome trapping limits the
efficiency of splicing correction by PNA-oligolysine conjugates” Journaof Controlled Release,
2006, 110, 595-604.
Seal, BL; Panitch, A, “Physicamatrices stabilized by enzymatically sensitive covalent crosslinks”
Acta Biomaterialia, 2006, 2, 241-251.
Busson, M; Castelli, FA; Wang, X-F; Cohen, WM; Charron, D; Ménez, A; Maillère, B, “Prediction
of CD4+ T celepitopes restricted to HLA-DP4 molecules” Journaof ImmunologicaMethods,
2006, 317, 144-151.
Stiffler, MA; Grantcharova, VP; Sevecka, M; MacBeath, G, “Uncovering Quantitative Protein
Interaction Networks for Mouse PDZ Domains Using Protein Microarrays”, J. Am. Chem. Soc.,
2006, 128, 5913-5922.
Chen, C-P; Kim, J; Steenblock, E; Liu, D; Rice, KG, “Gene Transfer with Poly-Melittin Peptides”,
Bioconjugate Chem., 2006, 17, 1057-1062.
Murata, S; Ladle, BH; Kim, PS; Lutz, ER; Wolpoe||, ME; Ivie, SE; Smith, HM; Armstrong, TD;
Emens, LA; Jaffee, EM; Reilly, RT. “OX40 Costimulation Synergizes with GM-CSF Whole-Cell
Vaccination to Overcome Established CD8+ T CelTolerance to an Endogenous Tumor Antigen”
J. Immun. 2006, 176, 974-983.
Sundararajan, N; Mao, D; Chan, S; Koo, T-W; Su, X; Sun, L; Zhang, J; Sung, K; Yamakawa, M;
Gafkem, PR; Randolph, T; McLerran, D; Feng, Z; Berlin, AA; Roth, MB, “Ultrasensitive Detection
and Characterization of PosttranslationaModifications Using Surface-Enhanced Raman
Spectroscopy”, Anal. Chem., 2006, 78, 3543-3550.
Sandberg, SM; Noser, JA; Cataliotti, A; Redfield, MM; Matsuda, Y; Burnett, JC., Jr. “BMPInduced
Activation of cGMP in Human Cardiac Fibroblasts: Interactions with Fibronectin and
Natriuretic Peptide Receptors”, J. Cell. Physiol., 2006, 209, 943-949.
Sewell, SL; Wright, DW, “Biomimetic Synthesis of Titanium Dioxide Utilizing the R5 Peptide
Derived from Cylindrotheca fusiformis”, Chem. Mater., 2006, 18, 3108-3113.
Hekim, C; Leinonen, J; Koistinen, H; Zhu, L; Koivunen, E; Vaisanen, V; Stenman, U-H, “Novel
Peptide Inhibitors of Human Kallilrein 2”, J. Biol. Chem., 2006, 281, 12555-12560.
Cohen, WM; Pouvelle-Moratille, S; Wang, X-F; Farci, S; Munier, G; Charron, D, Menez, A;
Busson, M; Maillere, B, “Scanning the HIV Genome for CD4+ T CelEpitopes Restricited to HLADP4,
the Most Prevalent HLA Class II Molecule”, J. Immun., 2006, 176, 5401-5407.
Murata, S; Ladle, BH; Kim, PS; Lutz, ER; Wolpoe, ME; Ivie, SE; Smith, HM; Armstrong, TD;
Emens, LA; Jaffee, EM; Reilly, RT, “OX40 Costimulation Synergizes with GM-CSF Whole-Cell
Vaccination to Overcome Established CD8+ T CelTolerance to an Endogenous Tumor Antigen”,
J. Immun., 2006, 176, 974-983.
Samel, SA; Wagner, B; Marahiel, MA; Essen, L-O, “The Thioesterase Domain of the Fengycin
Biosynthesis Cluster: A StructuraBase for the Macrocyclization of a Non-ribosomaLipopeptide”
Journaof Molecular Biology, 2006, 359, 876-889.
Kopp, F; Grünewald, J; Mahlert, C; Marahiel, MA, “Chemoenzymatic Design of Acidic Lipopeptide
Hybrids: New Insights into the Structure-Activity Relationship of Daptomycin and A54145”
Biochemistry, 2006, 45, 10474–10481.
Schracke, N; Linne, U; Mahlert, C; Marahiel, MA, “Synthesis of Linear Gramicidin Requires the
Cooperation of Two Independent Reductases” Biochemistry, 2005, 44, 8507–8513.
Grünewald, J; Kopp, F; Mahlert, C; Linne, U; Sieber, SA; Marahiel, MA, “Fluorescence
Resonance Energy Transfer as a Probe of Peptide Cyclization Catalyzed by Nonribosomal
Thioesterase Domains” Chemistry & Biology, 2005, 12, 873-881.
Zhang, Z; Liang, K; Bloch, S; Berezin, M; Achilefu, S, “Monomolecular MultimodaFluorescence-
Radioisotope Imaging Agents” Bioconjugate Chem., 2005, 16, 1232–1239.
Zhang, L; Li, B; Zhi, Z; Haynie, DT, “Perturbation of Nanoscale Structure of Polypeptide Multilayer
Thin Films” Langmuir, 2005, 21, 5439–5445.
Chew, GH; Galloway, LC; McIntyre, NR; Schroder, LA; Richards, KM; Miller, SA; Wright, DW;
Merkler, DJ, “Ubiquitin and ubiquitin-derived peptides as substrates for peptidylglycine α-
amidating monooxygenase” FEBS Letters, 2005, 579, 4678-4684.
Mahlert, C; Sieber, SA; Grünewald, J; Marahiel, MA, “Chemoenzymatic Approach to Enantiopure
Streptogramin B Variants: Characterization of Stereoselective Pristinamycin I Cyclase from
Streptromyces pristinaespialis”, J. Am. Chem. Soc., 2005, 127, 9571-9580.
Turner, JJ; Arzumanov, AA; Gait, MJ, “Synthesis, Cellular Uptake and HIV-1 Tat-dependednt
Trans-activation Inhibition Activity of Oligonucleotide Analogues Disulphide-Conjugated to Cell-
Penetrating Peptides”, Nucl. Acids Res., 2005, 33, 27-42.
Zhang, L; Parente, J; Harris, SM; Woods, DE; Hancock, REW; Falla, TJ, “AntimicrobiaPeptide
Therapeutics for Cystic Fibrosis”, Antimicrob. Agents Chemother., 2005, 49, 2921-2927.
Birtley, JR; Knox, SR; Jaulent, AM; Brick, P; Leatherbarrow, RJ; Curry, S, “CrystaStructure of
Foot-and-Mouth Disease Virus 3C Protease” J. Biol. Chem., 2005, 280, 11520-11527.
Fumoto, M; Hinou, H; Ohta, T; Ito, T; Yamada, K; Takimoto, A; Kondo, H; Shimizu, H; Inazu, T;
Nakahara, Y; Nishimura, S-I, “CombinatoriaSynthesis of MUC1 Glycopeptides: Polymer Blotting
Facilitates Chemicaａnd Enzymatic Synthesis of Highly Complicated Mucin Glycopeptides”, J.
Am. Chem. Soc., 2005, 127, 11804-11818.
Kamiński, ZJ; Kolesińska, B; Kolesińska, J; Sabatino, G; Chelli, M; Rovero, P; Błaszczyk, M;
Główka, ML; Papini, AM “N-Triazinylammonium Tetrafluoroborates. A New Generation of Efficient
Coupling Reagents Usefufor Peptide Synthesis”, J. Am. Chem. Soc., 2005, 127, 16912-16920.
Reynolds, F; Weissleder, R; Josephson, L, “Protamine as an Efficient Membrane-Translocating
Peptide”, Bioconjugate Chem., 2005, 16, 1240-1245.
Dartois, V; Sanchez-Quesada, J; Cabezas, E; Chi, E; Dubbelde, C; Dunn, C; Granja, J; Gritzen,
C; Weinberger, D; Ghadiri, MR; Parr, TR, Jr., “Systemic AntibacteriaActivity of NoveSynthetic
Cyclic Peptides”, Antimicrob. Agents Chemother., 2005, 49, 3302-3310.
Schracke, N; Linne, U; Mahlert, C; Maraheil, MA, “Synthesis of Linear Gramicidin Requires the
Coopreation of Two Independent Reductases”, Biochemistry, 2005, 44, 8507-8513.
Lolli, F; Mulinacci, B; Carotenuto, A; Bonetti, B; Sabatino, G; Mazzanti, B; D'Ursi, AM; Novellino,
E; Pazzagli, M; Lovato, L; Alcaro, MC; Peroni, E; Pozo-Carrero, MC; Nuti, F; Battistini, L;
Borsellino, G.;Chelli, M; Rovero, P; Papini, AM, “An N-glucosylated Peptide Detecting Disease-
Specific Autoantibodies, Biomarkers of Multiple Sclerosis”, PNAS, 2005, 102, 10273-10278.
Jaulent, AM; Leatherbarrow, RJ, “Design, Synthesis and Analysis of NoveBicyclic and
BifunctionaProtease Inhibitors” Protein Eng. Des. Sel., 2004, 17, 681-687.
Kelly, K; Alencar, H; Funovics, M; Mahmood, U; Weissleder, R, “Detection of Invasive Colon
Cancer Using a Novel, Targeted, Library-Derived Fluorescent Peptide” Cancer Res., 2004, 64,
6247-6251.
Pratt, MR; Hang, HC; Ten Hagen, KG; Rarick, J; Gerken, TA; Tabak, LA; Bertozzi, CR,
“Deconvoluting the Functions of Polypeptide N-α-Acetylgalactosaminyltransferase Family
Members by Glycopeptide Substrate Profiling” Chemistry & Biology, 2004, 11, 1009-1016.
Kelly, KA; Reynolds, F; Weissleder, R; Josephson, L, “Fluorescein isothiocyanate–hapten
immunoassay for determination of peptide–celinteractions” AnalyticaBiochemistry, 2004, 330,
181-185.
Grünewald, J; Sieber, SA; Mahlert, C; Linne, U; Marahiel, MA, “Synthesis and Derivatization of
Daptomycin” J. Am. Chem. Soc., 2004, 126, 17025–17031.
Galande, AK; Spatola, AF, “Solid-Phase Synthesis of Disulfide Heterodimers of Peptides” Org.
Lett., 2003, 5, 3431–3434.
Godkin, AJ; Smith, KJ; Willis, A; Tejada-Simon, MV; Zhang, J; Elliott, T; Hill, AVS, “Naturally
Processed HLA Class II Peptides ReveaHighly Conserved Immunogenic Flanking Region
Sequence Preferences That Reflect Antigen Processing Rather Than Peptide-MHC Interactions”
J. Immunol., 2001, 166, 6720-6727.
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