优质产品“Recombinant Murine IL-1β”价格
Catalog Number:
211-11B
Synonyms:
Catabolin, Lymphocyte-activating factor （LAF）, Endogenous Pyrogen （EP）, Leukocyte Endogenous Mediator （LEM）, Mononuclear Cell Factor （MCF）
Description:
IL-1β is a proinflammatory cytokine produced in a variety of cells including monocytes, tissue macrophages, keratinocytes and other epithelial cells. Both IL-1α and IL-1β binds to the same receptor and has similar if not identical biological properties. These cytokines have a broad range of activities including, stimulation of thymocyte proliferation, by inducing IL-2 release, B-cell maturation and proliferation, mitogenic FGF-like activity and the ability to stimulate the release of prostaglandin and collagenase from synovial cells. However, whereas IL-1β is a secreted cytokine, IL-1α is predominantly a cell-associated cytokine. Recombinant murine IL-1β is a 17.5 kDa protein containing 153 amino acid residues.
AA Sequence:
MVPIRQLHYR LRDEKSLV LSDPYELKAL HLNGQNIN VIFSMSFVQG EPSNDK*A LGLKGKNLYL SCVMKDGTPT LQLESVDPKQ YPKKKMEKRF VFNKIEVKSK VEFESAEFPN WYISTSQAEH KPVFLGNNSG QDIIDFTMES VSS
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 as determined by the dose-dependent stimulation of murine D10S cells is ≤ 0.002 ng/ml, corresponding to a specific activity of ≥ 5 x 108 units/mg.
Cross Reactivity:
Human, Monkey, Pig, Rat, Mouse + Chicken, Mouse, N/A, Mouse + Bacteria
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