中大发现M1天然病毒 癌细胞有望杀灭

在杀死癌细胞的同时，也杀死了正常细胞。”这个困惑着*医生和癌症病人的难题，终于可望破解。笔者13日从中山大学获悉，中山大学中山医学院教授颜光美课题组于7日在期刊《美国科学院院报》发表了天然甲病毒M1具有选择性抗肿瘤作用的研究，该研究表明，一种叫做M1的天然病毒能特异性杀死癌细胞而不伤害正常细胞，这种新型溶瘤病毒有望成为新一代抗癌利器

XY-EL-P0345c    猪血清素转运体(SERT)ELISA试剂盒    Porcine SERT (Serotonin Transporter ) ELISA Kit 
XY-EL-P0346c    猪葡萄糖转运蛋白2(GLUT2)ELISA试剂盒    Porcine GLUT2 (Glucose Transporter 2) ELISA Kit
XY-EL-P0347c    猪Rap鸟嘌呤交换因子1(RAPGEF1)ELISA试剂盒    Porcine RAPGEF1 (Rap Guanine Nucleotide Exchange Factor 1) ELISA Kit 
XY-EL-P0348c    猪核因子κB抑制蛋白β(IκBβ)ELISA试剂盒    Porcine IκBβ (Inhibitory Subunit of NF Kappa B Beta) ELISA Kit 
XY-EL-P0349c    猪微管相关蛋白2(MAP-2)ELISA试剂盒    Porcine MAP-2 (Microtubule Associated Protein 2) ELISA Kit
XY-EL-P0350c    猪6酮前列腺素(6-K-PG)ELISA试剂盒     Porcine 6-K-PG (6-Keto-prostaglandin) ELISA Kit
XY-EL-P0351c    猪原卟啉(EPP)ELISA试剂盒    Porcine EPP (Erythrocyte Protoporphyrin) ELISA Kit
XY-EL-P0352c    猪神经营养因子4(NT-4)ELISA试剂盒    Porcine NT-4 (Neurotrophin 4) ELISA Kit 
XY-EL-P0353c    猪核孔蛋白205kda(NUP205)ELISA试剂盒    Porcine NUP205 (Nucleoporin 205kDa) ELISA Kit
XY-EL-P0354c    猪肿瘤坏死因子受体超家族成员1A(TNFRSF1A)ELISA试剂盒    Porcine TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) ELISA Kit
XY-EL-P0356c    猪接触蛋白2(CNTN2)ELISA试剂盒    Porcine CNTN2 (Contactin 2) ELISA Kit 
XY-EL-P0357c    猪醛缩酶(ALD)ELISA试剂盒     Porcine ALD (Aldolase) ELISA Kit
XY-EL-P0358c    猪胰岛素样生长因子1受体(IGF1R)ELISA试剂盒    Porcine IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA Kit
XY-EL-P0360c    猪水通道蛋白2(AQP-2)ELISA试剂盒     Porcine AQP-2 (Aquaporin 2) ELISA Kit 
XY-EL-P0362c    猪酸性磷酸酶1(ACP1)ELISA试剂盒     Porcine ACP1 (Acid Phosphatase 1) ELISA Kit
XY-EL-P0363c    猪延伸蛋白A(EloA)ELISA试剂盒     Porcine EloA (Elongin A) ELISA Kit
XY-EL-P0364c    猪丝氨酸蛋白酶23(PRSS23)ELISA试剂盒    Porcine PRSS23 (Protease, Serine 23) ELISA Kit 
XY-EL-P0365c    猪八聚体结合转录因子1(OBTF1)ELISA试剂盒    Porcine OBTF1 (Octamer Binding Transcription Factor 1) ELISA Kit 
XY-EL-P0366c    猪组织蛋白酶C(CTSC)ELISA试剂盒      Porcine CTSC (Cathepsin C) ELISA Kit
XY-EL-P0367c    猪神经丝蛋白(NF)ELISA试剂盒    Porcine NF (Neurofilament) ELISA Kit
XY-EL-P0369c    猪肌肉磷酸果糖激酶(PFKM)ELISA试剂盒     Porcine PFKM (Phosphofructokinase, Muscle) ELISA Kit
XY-EL-P0370c    猪硫氧化还原蛋白(Trx)ELISA试剂盒    Porcine Trx (Thioredoxin) ELISA Kit
XY-EL-P0372c    猪重肽铁蛋白(FTH)ELISA试剂盒    Porcine FTH (Ferritin, Heavy Polypeptide) ELISA Kit 
XY-EL-P0373c    猪葡萄糖6磷酸异构酶(GPI)ELISA试剂盒      Porcine GPI (Glucose 6 Phosphate Isomerase) ELISA Kit
XY-EL-P0374c    猪丝裂原激活蛋白激酶激酶6(MAP2K6/MKK6)ELISA试剂盒    Porcine MAP2K6/MKK6 (Mitogen Activated Protein Kinase Kinase 6) ELISA Kit
XY-EL-P0375c    猪心肌营养素样细胞因子1(CLCF1)ELISA试剂盒     Porcine CLCF1 (Cardiotrophin Like Cytokine Factor 1) ELISA Kit 
XY-EL-P0376c    猪锚蛋白B(Ank-B)ELISA试剂盒     Porcine Ank-B (Ankyrin B) ELISA Kit
XY-EL-P0377c    猪白细胞分化抗原CD97(CD97)ELISA试剂盒     Porcine CD97 (Cluster of Differentiation 97) ELISA Kit 
XY-EL-P0379c    猪二氢嘧啶酶样2(DPYSL2)ELISA试剂盒     Porcine DPYSL2 (Dihydropyrimidinase Like Protein 2) ELISA Kit
XY-EL-P0380c    猪钙周期蛋白结合蛋白(CACYBP)ELISA试剂盒    Porcine CACYBP (Calcyclin Binding Protein) ELISA Kit 
XY-EL-P0382c    猪环腺苷二磷酸核糖水解酶(cADPRH/CD38)ELISA试剂盒    Porcine cADPRH/CD38 (Cyclic ADP Hydrolase) ELISA Kit
XY-EL-P0383c    猪转录激活因子-1(ATF-1)ELISA试剂盒     Porcine ATF-1 (Activating Transcription Factor 1) ELISA Kit
XY-EL-P0384c    猪速激肽受体2(TACR2)ELISA试剂盒    Porcine TACR2 (Tachykinin Receptor 2) ELISA Kit
XY-EL-P0385c    猪补体受体2 (CR2/CD21)ELISA试剂盒     Porcine CR2/CD21 (Complement Receptor 2) ELISA Kit

癌症发病率呈现快速增长态势，现有的治疗手段远远未能满足临床需求。颜光美课题组历经多年研究，从海南岛分离得到一种M1的天然病毒。颜光美团队使用细胞培养方法发现，M1病毒能选择性地感染并杀死包括肝癌、结直肠癌、膀胱癌、黑色素瘤在内的多种癌细胞，而对正常细胞无毒副作用。整体动物模型证明，M1病毒“像长了眼睛一样准确找到肿瘤组织并将其杀灭”，正常细胞则不受影响。

除细胞水平及动物实验之外，课题组还使用临床标本离体活组织培养模型进一步证实了上述新型溶瘤病毒的有效性和特异性