治疗败血症的关键性酶

败血症是由致病菌侵入血液循环并在其中生长繁殖，产生毒素而引起的全身性感染，易在人体抵抗力降低的情况下发生。严重的败血症会威胁病人的重要器官

近日，UBC研究员Keith Walley等人证实：抑制或减少PCSK9，可能帮助患者身体清除细菌和真菌的有毒残余（抗生素抗击细菌和真菌后所剩下的废物）。处理掉感染废弃物可改善患者的预后和存活率。

使用PCSK9抑制剂治疗严重脓毒症小鼠，能增加其存活率。由遗传变异导致PCSK9水平减少的小鼠也表现出败血症结果和存活率得到改善。

XY-EL-H0001c    人α1酸性糖蛋白(α1-AGP)ELISA试剂盒    Human α1-AGP (Alpha-1-Acid Glycoprotein) ELISA Kit
XY-EL-H0002c    人血管紧张素转化酶 (ACE)ELISA试剂盒    Human ACE (Angiotensin I Converting Enzyme) ELISA Kit
XY-EL-H0003c    人激活素A(ACVA)ELISA试剂盒    Human ACVA (Activin A) ELISA Kit
XY-EL-H0004c    人脂联素(ADP/Acrp30)ELISA试剂盒    Human ADP/Acrp30 (Adiponectin) ELISA Kit
XY-EL-H0005c    人Agouti相关蛋白(AgRP)ELISA试剂盒    Human AgRP (Agouti Related Protein) ELISA Kit
XY-EL-H0006c    人血管生成素(ANG)ELISA试剂盒    Human ANG (Angiogenin) ELISA Kit
XY-EL-H0007c    人促血管生成素1(ANG1)ELISA试剂盒    Human ANG1 (Angiopoietin 1) ELISA Kit
XY-EL-H0008c    人促血管生成素2(ANG2)ELISA试剂盒    Human ANG2 (Angiopoietin 2) ELISA Kit
XY-EL-H0009c    人B细胞活化因子 (BAFF/CD257)ELISA试剂盒     Human BAFF/CD257 (B-Cell Activating Factor) ELISA Kit
XY-EL-H0010c    人脑源性神经因子(BDNF)ELISA试剂盒     Human BDNF (Brain Derived Neurotrophic Factor) ELISA Kit
XY-EL-H0011c    人骨成型蛋白2 (BMP-2)ELISA试剂盒     Human BMP-2 (Bone Morphogenetic Protein 2) ELISA Kit
XY-EL-H0012c    人骨成型蛋白4 (BMP-4)ELISA试剂盒     Human BMP-4 (Bone Morphogenetic Protein 4) ELISA Kit
XY-EL-H0013c    人骨成型蛋白7 (BMP-7)ELISA试剂盒     Human BMP-7 (Bone Morphogenetic Protein 7) ELISA Kit
XY-EL-H0014c    人上皮型钙黏蛋白 (E-Cad)ELISA试剂盒     Human E-Cad (E-Cadherin) ELISA Kit
XY-EL-H0015c    人碳酸酐酶IX (CA9)ELISA试剂盒    Human CA9 (Carbonic Anhydrase IX) ELISA Kit
XY-EL-H0016c    人胱天蛋白酶1(CASP1)ELISA试剂盒    Human CASP1 (Caspase 1) ELISA Kit
XY-EL-H0017c    人半胱天冬酶3(CASP3)ELISA试剂盒    Human CASP3 (Caspase 3) ELISA Kit
XY-EL-H0018c    人组织蛋白酶B(CTSB)ELISA试剂盒    Human CTSB (Cathepsin B) ELISA Kit
XY-EL-H0019c    人组织蛋白酶V(CTSV)ELISA试剂盒    Human CTSV (Cathepsin V) ELISA Kit
XY-EL-H0020c    人单核细胞趋化蛋白1(MCP-1)ELISA试剂盒    Human MCP-1 (Monocyte Chemotactic Protein 1) ELISA Kit
XY-EL-H0021c    人巨噬细胞炎性蛋白1α(MIP-1α)ELISA试剂盒    Human MIP-1α (Macrophage Inflammatory Protein 1 Alpha) ELISA Kit 
XY-EL-H0022c    人巨噬细胞炎性蛋白1β(MIP-1β)ELISA试剂盒     Human MIP-1β (Macrophage Inflammatory Protein 1 Beta) ELISA Kit 
XY-EL-H0023c    人调节正常T细胞表达和分泌因子(RANTES)ELISA试剂盒     Human RANTES (Regulated On Activation, Normal T-Cell Expressed and Secreted) ELISA Kit 
XY-EL-H0024c    人单核细胞趋化蛋白3(MCP-3)ELISA试剂盒    Human MCP-3 (Monocyte Chemotactic Protein 3) ELISA Kit
XY-EL-H0025c    人嗜酸粒细胞趋化因子(ECF/CCL11)ELISA试剂盒    Human ECF/CCL11 (Eosinophil Chemotactic Factor) ELISA Kit
XY-EL-H0026c    人胸腺激活调节趋化因子(TARC)ELISA试剂盒    Human TARC (Thymus Activation Regulated Chemokine) ELISA Kit
XY-EL-H0027c    人巨噬细胞炎性蛋白3α(MIP-3α)ELISA试剂盒    Human MIP-3α (Macrophage Inflammatory Protein 3 Alpha) ELISA Kit 
XY-EL-H0028c    人二级淋巴组织趋化因子(SLC)ELISA试剂盒    Human SLC (Secondary Lymphoid Tissue Chemokine) ELISA Kit
XY-EL-H0029c    人巨噬细胞来源的趋化因子(MDC)ELISA试剂盒    Human MDC (Macrophage Derived Chemokine) ELISA Kit
XY-EL-H0030c    人髓样前体细胞抑制因子2(MPIF2)ELISA试剂盒    Human MPIF2 (Myeloid Progenitor Inhibitory Factor 2) ELISA Kit
XY-EL-H0031c    人巨噬细胞炎性蛋白4α(MIP4α)ELISA试剂盒    Human MIP4α (Macrophage Inflammatory Protein 4 Alpha) ELISA Kit
XY-EL-H0032c    人皮肤T细胞虏获趋化因子(CTACK)ELISA试剂盒     Human CTACK (Cutaneous T-cell Attracting Chemokine) ELISA Kit
XY-EL-H0033c    人可溶性CD14分子(sCD14)ELISA试剂盒    Human sCD14 (Soluble Cluster of Differentiation14) ELISA Kit
XY-EL-H0034c    人免疫球蛋白E Fc段受体Ⅱ(FcεRⅡ/CD23)ELISA试剂盒     Human FcεRII/CD23 (Receptor II for the Fc Region of Immunoglobulin E) ELISA Kit
XY-EL-H0035c    人白细胞分化抗原CD40配体(CD40L/TNFSF5)ELISA试剂盒    Human CD40L/TNFSF5 (Cluster of Differentiation 40 Ligand) ELISA Kit
XY-EL-H0036c    人CD163分子(CD163)ELISA试剂盒    Human CD163 (Cluster of Differentiation 163) ELISA Kit
XY-EL-H0037c    人软骨糖蛋白39(GP39)ELISA试剂盒     Human GP39 (Glycoprotein 39, Cartilage) ELISA Kit
XY-EL-H0038c    人丛生蛋白(CLU)ELISA试剂盒    Human CLU (Clusterin) ELISA Kit
XY-EL-H0039c    人睫状神经营养因子(CNTF)ELISA试剂盒     Human CNTF (Ciliary Neurotrophic Factor) ELISA Kit 

许多制药公司目前正在开发PCSK9抑制剂，用以增加对胆固醇的清除作用，从而降低心血管疾病风险。这就为用PCSK9抑制剂治疗感染性患者带来了可能