产品编号 yb-6006R
英文名称 Anti-FBXO31抗体
中文名称 F-box蛋白家族FBXO31抗体
别    名 F box only protein 31; FBX14; FBX31; FBXO14; pp2386; Putative breast cancer tumor suppressor; SCF ubiquitin ligase specificity factor; FBX31_HUMAN.
 Anti-FBXO31抗体  
说 明 书 0.2ml  
研究领域 肿瘤  细胞生物  免疫学  
抗体来源 Rabbit
克隆类型 Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, 
产品应用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 61kDa
性    状 Lyophilized or Liquid
浓    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human FBXO31 (170-225aa)
亚    型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
 
PubMed PubMed
产品介绍 background:
FBXO31 belongs to the F-box protein family. Such proteins are characterized by an F-box motif of approximay 40 residues. F-box proteins interact with SKP1 through the F box and they interact with ubiquitination targets through other protein interaction domains. There are two different isoforms.

Function:
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor.

Subunit:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex.

Tissue Specificity:
Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow.
 
Post-translational modifications:
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization.