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厦门慧嘉生物科技有限公司
PF 4 Human /人血小板因子-4(CXCL4)产品编号:CHM-234
产品规格:5μg/20μg/1mg
Synonyms | CXCL4, PF-4, PF4, Iroplact, Oncostatin-A, SCYB4, MGC138298. |
Introduction | Plaet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated plaets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. Oncostatin-A is a member of the CXC chemokine family. Human PF4 is used for the proof of heparin-induced thrombocytopenia. Furthermore it is used as an inhibitor in the angiogenesis during tumor therapy. |
Description | Human PF-4 a 7.8 kDa protein consisting of 70 amino acid residues. |
Source | Human Plaets. |
Physical Appearance | Sterile Filtered white lyophilized powder. |
Formulation | The CXCL4 protein was lyophilized in PBS buffer. |
Solubility | It is recommended to reconstitute the lyophilized CXCL4 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions. |
Stability | Human CXCL4 although stable at 25°C 1 week, should be stored desiccated below -18°C. Please prevent freeze-thaw cycles. |
Purity | Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE. |
Amino acid sequence | The sequence of the first four N-terminal amino acids was determined and was found to be Glu-Ala-Glu-Glu. |
Activity Control | Binding of HIT-antibodies. |
Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY.They may not be used as drugs,agricultural or pesticidal products, food additives or household chemicals. |
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