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IGFBP 1 Human /人胰岛素样生长因子结合蛋白-1 产品编号：CYT-299

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IGFBP 1 Human /人胰岛素样生长因子结合蛋白-1 产品编号：CYT-299
产品规格：5μg/20μg/1mg

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IGFBP 1 Human /人胰岛素样生长因子结合蛋白-1

产品编号：CYT-299
产品规格：5μg/20μg/1mg

Synonyms	IBP-1, IGF-Binding Protein 1, AFBP, PP12, IGF-BP25, hIGFBP-1, IGFBP-1.
Intorduction	IGFBP1 is a member of the insulin-like growth factor binding protein （IGFBP） family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors （IGFs） I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Description	Insulin-like Growth Factor Binding Protein-1 Human Recombinant is a single, glycosylated, polypeptide chain containing 218 amino acids and having a molecular mass of 28806 Dalton. IGF-Binding Protein 1 is purified by proprietary chromatographic techniques.
Source	NSO cells.
Physical Appearance	Sterile Filtered White lyophilized （freeze-dried） powder.
Formulation	The protein was lyophilized with 10mM HCL.
Solubility	It is recommended to reconstitute the lyophilized IBP-1 in sterile 18MΩ-cm H2O not less than 100μg/ml, which can then be further diluted to other aqueous solutions.
Stability	Lyophilized IGFBP1 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IGF-BP1 should be stored at 4°C between 2-7 days and for future use below -18°C. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Please prevent freeze-thaw cycles.
Purity	Greater than 95.0% as determined by（a） Analysis by RP-HPLC. （b） Analysis by SDS-PAGE.
Biological Activity	Inhibition of IGF-I stimulated proliferation of NUC-1 cells: IC50 ~ 100 ng/ml Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures: IC50 （1% serum） ~300 ng/ml.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.