脂溶水溶交联剂的选择、作用和目录
什么是交联剂
交联剂是一类小分子化合物，分子量一般在200-600之间，具有2个或者更多的针对特殊基团（氨基、巯基等）的反应性末端，可以和2个或者更多的分子分别偶联从而使这些分子结合在一起。在生命科学研究中，巧妙地运用交联剂可以使很多工作取得突破。
交联剂的应用
交联剂已经被广泛地应用于：细胞膜结构研究，蛋白质结构研究，蛋白质间相互作用研究，生物导*研究，载体蛋白与半抗原的连接，蛋白质或其他分子的固相化，抗体的标记，标记转移，蛋白质与核酸的连接。
如何选择交联剂
选择交联剂时要综合考虑这些因素：反应指向，间臂长度，水溶性，透膜性，可否切断，可否碘化。
西安凯新生物交联剂的特点
· 种类zui多，成熟的产品多达上百种，可以满足各种偶联需要。
· 生*条件下即可共价交联，交联反应快速简便。
· 多种反应性基团可供选择，反应指向既可以有专一性也可以无专一性。
· 含有不同长度的间臂，有效地降低空间位阻效应。
· 部分产品内置可裂解基团，大大增强了交联剂应用的灵活性。
西安凯新生物交联剂一览
以下是西安凯新生物交联剂所谓部分产品，有每一种交联剂的全称、分子式、分子量、间臂长度、特征优点、包装规格等，详细资料请进入公司展台查看
以上资料由西安凯新生物科技有限公司提供，如需详询请进入展台查看或电询或者
Heterobifunctional Crosslinker Selection Guide
Crosslinker
Acronym | Spacer Arm
Length | M.W. | Reactivity | Cleavable
By | Membrane
Permeable | Water
Soluble |
ANB-NOS | 7.7 Å | 305.2 | -NH2 ;
-NH2, -C=C-, -CH, -NH | - | Yes | No |
BMPS | 5.9 Å | 266.2 | -NH2 ; -SH2 | - | Yes | No |
EMCS | 9.4 Å | 308.3 | -NH2 ; -SH2 | - | Yes | No |
GMBS | 7.3 Å | 280.2 | -NH2 ; -SH2 | - | Yes | No |
LC-SPDP | 15.7 Å | 425.5 | -NH2 ; -SH2 | Thiols | Yes | No |
MBS | 7.3 Å | 314.3 | -NH2 ; -SH2 | - | Yes | No |
PDPH | 9.2 Å | 229.3 | -SH2;-CHO | Thiols | Yes | Yes |
SBA | 1.5 Å | 236.0 | -NH2 ; -SH2 | - | Yes | No |
SIA | 1.5 Å | 283.0 | -NH2 ; -SH2 | - | Yes | No |
Sulfo-SIA | 1.5 Å | 385.1 | -NH2 ; -SH2 | - | No | Yes |
SMCC | 8.3 Å | 334.3 | -NH2 ; -SH2 | - | Yes | No |
SMPB | 11.6 Å | 356.3 | -NH2 ; -SH2 | - | Yes | No |
SMPH | 14.3 Å | 379.4 | -NH2 ; -SH2 | - | Yes | No |
SPDP | 6.8 Å | 312.4 | -NH2 ; -SH2 | Thiols | Yes | No |
Sulfo-LC-SPDP | 15.7 Å | 527.6 | -NH2 ; -SH2 | Thiols | No | Yes |
Sulfo-MBS | 7.3 Å | 416.3 | -NH2 ; -SH2 | - | No | Yes |
Sulfo-SANPAH | 18.2 Å | 492.4 | -NH2 ;
-NH2, -C=C-, -CH, -NH | - | No | Yes |
Sulfo-SMCC | 8.3 Å | 436.4 | -NH2 ; -SH2 | - | No | Yes |
Homobifunctional Crosslinker Selection Guide
Crosslinker
Acronym | Spacer Arm
Length | M.W. | Reactivity | Cleavable
By | Membrane
Permeable | Water
Soluble |
BS2G | 7.7 Å | 530.4 | -NH2 ; -NH2 | - | No | Yes |
BS3 | 11.4 Å | 572.4 | -NH2 ; -NH2 | - | No | Yes |
DSG | 7.7 Å | 326.3 | -NH2 ; -NH2 | - | Yes | No |
DSP | 12.0 Å | 404.4 | -NH2 ; -NH2 | Thiols | Yes | No |
DSS | 11.4 Å | 368.3 | -NH2 ; -NH2 | - | Yes | No |
DSSeb | 14.1 Å | 396.4 | -NH2 ; -NH2 | - | Yes | No |
DST | 6.4 Å | 344.2 | -NH2 ; -NH2 | Periodate | Yes | Yes |
DTSSP | 12.0 Å | 608.5 | -NH2 ; -NH2 | Thiols | No | Yes |
EGS | 16.1 Å | 456.4 | -NH2 ; -NH2 | Hydroxylamine | Yes | No |
Sulfo-EGS | 16.1 Å | 660.5 | -NH2 ; -NH2 | Hydroxylamine | No | Yes |
Zero-length Crosslinker Selection Guide
Crosslinker
Acronym | Spacer Arm
Length | M.W. | Reactivity | Cleavable
By | Membrane
Permeable | Water
Soluble |
CDI | 0.0 Å | 162.2 | -NH2 ; -COOH | - | n/a | *reacts |
DCC | 0.0 Å | 206.3 | -NH2 ; -COOH | - | Yes | No |
EDC-HCl | 0.0 Å | 191.7 | -NH2 ; -COOH | - | No | Yes |
NHS | 0.0 Å | 115.1 | -NH2 ; -COOH | - | Yes | No |
Sulfo-NHS | 0.0 Å | 217.1 | -NH2 ; -COOH | - | No | Yes |
Deuterated Crosslinker Selection Guide
Crosslinker
Acronym | Spacer Arm
Length | M.W. | Reactivity | Cleavable
By | Membrane
Permeable | Water
Soluble |
BS2G-d4 | 7.7 Å | 534.4 | -NH2 ; -NH2 | - | No | Yes |
BS3-d4 | 11.4 Å | 576.5 | -NH2 ; -NH2 | - | No | Yes |
DSG-d4 | 7.7 Å | 330.3 | -NH2 ; -NH2 | - | Yes | No |
DSP-d8 | 12.0 Å | 412.5 | -NH2 ; -NH2 | Thiols | Yes | No |
DSS-d4 | 11.4 Å | 372.4 | -NH2 ; -NH2 | - | Yes | No |
Biotinylation Reagent Selection Guide
Crosslinker
Acronym | Spacer Arm
Length | M.W. | Reactivity | Cleavable
By | Membrane
Permeable | Water
Soluble |
NHS-Biotin | 13.5 Å | 341.4 | -NH2 | - | Yes | No |
NHS-LC-Biotin | 22.4 Å | 454.5 | -NH2 | - | Yes | No |
NHS-SS-Biotin | 24.3 Å | 504.7 | -NH2 | Thiols | Yes | No |
Sulfo-NHS-Biotin | 13.5 Å | 443.4 | -NH2 | - | No | Yes |
Sulfo-NHS-LC-Biotin | 22.4 Å | 556.6 | -NH2 | - | No | Yes |
Sulfo-NHS-SS-Biotin | 24.3 Å | 606.7 | -NH2 | Thiols | No | Yes |
Biotin-HPDP | 29.2 Å | 539.8 | -SH2 | Thiols | Yes | No |
Iodoacetyl-LC-Biotin | 27.1 Å | 510.4 | -SH2 | - | Yes | No |
Biotin Hydrazide | 15.7 Å | 258.3 | -CHO | - | Yes | No |
D-Biotin | 13.5 Å | 244.3 | -NH2* | - | No | Yes |
以上资料由西安凯新生物科技有限公司提供，如需详询请进入展台查看或电询或者
其他交联剂
Crosslinking Reagents
Protein-Protein Crosslinking Kits
Lys-to-Lys Protein-Protein Conjugation Kit
Bis-Alkylating Reagents
ThioLinker NHS Ester
Bis-sulfone-PEG4-DBCO
Bis-sulfone-PEG4-Tetrazine
ThioLinker-Azide
Bis-sulfone-PEG3-Azide
Bis-sulfone Amine
Bis-sulfone Acid
ThioLinker Acid
Bis-sulfone NHS Ester
Bis-sulfone-PEG4-NHS Ester
ThioLinker NHS Ester
Biotin Labeling Reagents
Desthiobiotinylation Reagents
Desthiobiotin-PEG3-Azide
Desthiobiotin NHS Ester
Desthiobiotin-PEG4-Alkyne
TAMRA-Azide-Desthiobiotin
DBCO-PEG4-Desthiobiotin
Biotin-PEG12-NHS Ester
Biotin-Sulfo-NHS Ester
Biotin-NHS Ester
Dde Biotin-PEG4-NHS ester
PC Biotin-NHS ester
Biotin-PEG4-NHS Ester
Biotin-NHS Ester
Sulfhydryl Reactive
UV-Tracer Biotin-Maleimide
Biotin-PEG3-Maleimide
Cleavable Biotin Probes
Dde Biotin-Azide
Dde Biotin Picolyl Azide
Diazo Biotin-Azide
Disulfide Biotin Azide
PC Biotin-Azide
Diol Biotin-Azide
PC Biotin-Alkyne
Dde Biotin-Alkyne
Diol Biotin-Alkyne
Dde Biotin-DBCO
Diazo Biotin-Alkyne
PC DBCO-Biotin
WS PC DBCO-Biotin
Diazo Biotin-DBCO
Disulfide DBCO Biotin
Click Chemistry
Biotin-PEG3-Azide
Biotin Picolyl Azide
TAMRA-Biotin-Azide
Biotin-PEG4-Methyltetrazine
Fluorescein-Biotin-Azide
以上资料由西安凯新生物科技有限公司提供，如需详询请进入展台查看或电询或者
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