上海研盟生物有限公司*品质供应Anti-Acid sphingomyelinase抗体，我公司销售国内外科研产品，如生物试剂、生化试剂，一抗二抗，各种标记抗体，Elisa酶联免疫试剂盒，放免试剂盒，培养基，各种动物血清等产品，欢迎广大新老客户前来咨询订购，订购:或。

酸性神经鞘磷脂酶抗体,Anti-Acid sphingomyelinase抗体简单介绍：

中文名称：酸性神经鞘磷脂酶抗体

英文名称：Anti-Acid sphingomyelinase抗体

别 名：Acid sphingomyelinase; ASM; ASM_HUMAN; aSMase; NPD; Smpd1; Sphingomyelin phosphodiesterase 1 acid lysosomal; Sphingomyelin phosphodiesterase.  

此产品本公司有标记的一抗出售，相关标记有：Alexa Fluor 350 标记、Alexa Fluor 488 标记、Alexa Fluor 555 标记、Alexa Fluor 647 标记、AP标记、APC标记、Biotin标记、Cy3标记、Cy5标记、Cy5.5标记、Cy7标记、FITC标记、Gold标记、HRP标记、PE标记、PE-Cy3标记、PE-CY5标记、PE-CY5.5标记、PE-CY7标记、RBITC标记

背景介绍：Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity.
Involvement in disease: Defects in SMPD1 are the cause of Niemann-Pick disease type A (NPDA) ; also known as Niemann-Pick disease classical infantile form. It is an early-onset lysosomal storage disorder caused by failure to hydrolyze sphingomyelin to ceramide. It results in the accumulation of sphingomyelin and other metabolically related lipids in reticuloendothelial and other cell types throughout the body, leading to cell death. Niemann-Pick disease type A is a primarily neurodegenerative disorder characterized by onset within the first year of life, mental retardation, digestive disorders, failure to thrive, major hepatosplenomegaly, and severe neurologic symptoms. The severe neurological disorders and pulmonary infections lead to an early death, often around the age of four. Clinical features are variable. A phenotypic continuum exists between type A (basic neurovisceral) and type B (purely visceral) forms of Niemann-Pick disease, and the intermediate types encompass a cluster of variants combining clinical features of both types A and B.

规格：0.1ml/0.2ml

浓度：1mg/1ml

抗体来源：本公司抗体有兔来源和鼠来源等

克隆类型：兔来源为多抗，鼠来源为单抗

产品类型：一抗

酸性神经鞘磷脂酶抗体保存条件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

避免反复冻融，保质期一年。

酸性神经鞘磷脂酶抗体,Anti-Acid sphingomyelinase抗体免疫组化问题解答

1、染色过强？

原 因：抗体浓度过高或孵育时间过长

解决方法：降低抗体滴度、抗体孵育时间：室温1小时或4度过夜

原 因：孵育温度过高超过37度

解决方法：一般在室温20-28度

原 因：DAB显色时间过长或浓度过高

解决方法：显色时间不超过5-12分钟，以显微镜下观察为准

2、非特异性背景染色？

原 因：操作过程中冲洗不充分

解决方法：每步冲洗3次每次5分钟

原 因：组织中含过氧化物酶未阻断

解决方法：可再配置新鲜3%H2O2封闭孵育时间延长

原 因：组织中含内原性*

解决方法：正常非免疫动物血清再封闭

原 因：血清蛋白封闭不充分

解决方法：血清蛋白封闭不充分

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