SynTumor 3D 肿瘤模型芯片-世联博研（北京）科技有限公司

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SynTumor Kits and Chips	Starter Kit (microvascular) Cat#s 403004, 403008	Assay Kit (microvascular) Cat#s 403003, 403007	Starter Kit (idealized) Cat#s 403002, 403006	Assay Kit (idealized) Cat#s 403001, 403005
102004-STu (2uM) or 102012-STu (8uM) Chips (10)			?	?
105007-STu (2uM) or 105015-STu (8uM) Chips (10)	?	?
Pneumatic Primer and Adapter	?		?
Manifold (5 port)	?		?
Blunt Tip Needles 0.5�� long, 24ga (50)	?	?	?	?
Tygon Tubing 0.2�� ID x 0.6�� OD (100 ft)	?	?	?	?
1 mL Syringes (50)	?	?	?	?
Slide Clamps (25)	?	?	?	?

SynTumor 3D Cancer Model Predicts In Vivo Drug Delivery Vehicle Responses

3D culture of endothelial cells and breast cancer cells were evaluated for their viability following treatment with chemotherapeutic drugs. SynTumor model demonstrated significant differences in drug responses under static conditions compared to perfusion and diffusion based modes of interaction commonly observed in vivo.

SynVivo and in vivo response show that both the nanopolymers labeled A and B transfect the core of the tumor with uniform GFP expression following direct injection. In contrast, vascular injection route in SynVivo shows uniform transfection of the tumors only for nanopolymer labeled A matching the observed results in vivo.

Differences between vascular diffusion and perfusion experiments on tumor and endothelial cell viability. Vascular flow and diffusion allows formation of necrotic core similar to in vivo.

Plot of viable cells for the two different modes of drug exposure compared to classical well plate studies. Results from well plate studies over predict the efficacy responses.

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