生物力学相关产品及科研服务

多功能多轴向组织材料力学特性分析仪
微纳自动压痕仪
3D轮廓测量3D PROFILOMETRY
Arthro-BST软骨流动电位评估系统
组织材料摩擦磨损剪切模量测试系统
biotester生物材料双轴测试系统
MicroSquisher多种微力测试分析系统
UniVert单轴拉伸、压缩和扭力测试分析
Flexcell细胞拉压流体剪切培养仪
单层细胞压力加载培养与实时观察分析系统
TGT三维血管软骨皮肤应力培养系统
血管生物反应器
肌腱韧带生物反应器
软骨生物反应器
旋转灌流生物反应器
骨组织灌流表型生物反应器
皮肤生物反应器
凝胶支架种子细胞构建生物组织系统
皮肤弹性测试分析仪
ITI单层细胞静水压力培养系统
细胞牵引力显微镜
细胞组织力学特性定量分析光镊
离体或活体在体骨参考点压痕测量分析仪
高通量细胞力学特性分析流式细胞仪
血管血流循环模拟系统
VCU颅脑损伤仪
三维微流控芯片系统
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biomomentum多功能微观生物力学系统之材料组织微力剪切力、摩擦磨损测试分析

多功能组织材料生物力学特性、电位分布测试分析表征系统
-多载荷多物理场耦合微观力学性能原位测试系统

- 材料组织微力剪切、摩擦磨损测试分析

剪切shear

剪切试验可用于评估平面剪切或扭转中的材料的剪切模量g。当在平行于其运动的方向上施加力时，剪切模量表示材料的刚度。平衡剪切模量G被描述为剪切应变上的剪切应力。两种配置通常用于确定剪切模量：平面剪切，其遵循横轴（x或y轴）和扭转剪切，其遵循旋转轴。在平面剪切的构造下，假设样品是一个的矩形棱镜，其在应力下具有一个表面，其相对的表面受约束。在扭转剪切的构造下，假设样品是一个的圆柱（惯性矫正力矩可以施加用于其他形状），其顶部和底表面完Quan连接到两个压板（非滑动边界条件）。

摩擦

摩擦测试确定两个表面在接触力作用下相互滑动的难易程度。在这些试验中通常观察到两种主要现象:静摩擦和动摩擦。静摩擦力是阻止物体从静止状态移动的力，而动摩擦力是当两个表面已经在运动时作用在它们之间的力。使用垂直平台施加法向力，其他平台施加旋转或平移运动，由Biomomentum开发的软件允许您轻松确定摩擦系数和测试中涉及的力。摩擦测试的目的涵盖了一个很大的兴趣领域。例如，测试一种新型润滑剂的有效性或比较两个样品的表面性质。

压痕亮点特点

1、力范围跨度大：uN到250N

2、可以测试软骨和隐形眼睛摩擦力

3、产品成熟，文献量大（数百篇）

4、多力偶联测试，如测量旋转中两个软骨表面之间的摩擦系数

5、微力测试隐形眼睛摩擦测试

该系统是能集成压缩、张力、剪切、摩擦、扭转和2D/3D压痕、3D轮廓及多力混合耦连测试的一体化微观力学测试装置。能对生物组织、聚合物、凝胶、生物材料、胶囊、粘合剂和食品进行精密可靠的机械刺激和表征。允许表征的机械性能包括刚度、强度、模量、粘弹性、塑性、硬度、附着力、肿胀和松弛位移控制运动。

特点

1、适用样品范围广：

1.1、从骨等硬组织材料到脑组织、眼角膜等软组织材料

1.2、从粗椎间盘的样品到j细纤维丝

2、通高量压痕测试分析

2.1、三维法向压痕映射非平面样品整个表面的力学特性

2.2、48孔板中压痕测试分析

3、力学类型测试分析功能齐

模块化集成压缩、张力、剪切、摩擦、扭转、穿刺、摩擦和2D/3D压痕、3D表面轮廓、3D厚度、粘合、塔接结合力等各种力学类型支持,微观结构表征及动态力学分析研究

4、高分辨率:

4.1、位移分辨率达0.1um

4.2、力分辨率达0.025mN

5、行程范围广：50-250mm

6、体积小巧、可放入培养箱内

7 、高变分辨率成像跟踪分析

8、多轴向、多力偶联刺激

9、活性组织电位分布测试分析

10、产品成熟，文献量达上千篇

该微观力学测试分析与培养系统初该系统为软骨力学性能检测所研发，此后集成了多种配置以满足更多生物组织和软质材料力学性能的测量和评估。该仪器性能特点--模块化设计，简易操作平台，面向用户设计，广泛应用于生物材料检测，高分子材料检测以及数字教学等领域，产品得到了业界广泛的认可和推广。该系统

相比于传统的大型力学测试系统，该微观力学测试系统总体较小，可以实现桌面化的操作流程，操作过程简便。该系统测试方法面，是多样化的材料力学表征工具，是科学家、工程师和其他各领域用户的佳选择。在动态力学分析、薄膜、复合物、聚合物、生物产品、医学鉴定和水凝胶等领域都有广泛应用。

Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21

OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode particularly important for maintenance of the normally pristine articular surface. A boundary mode of lubrication is indicated by a kinetic friction coefficient being...

Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256

Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates...Read More

Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrａnd A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016

In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More

ASTM D1894 - Standard Test Method for Static and Kinetic Coefficients of Friction of Plastic Film and SheetingASTM International, West Conshohocken, PA, 2014,

Significance and Use

4.1 Measurements of frictional properties may be made on a film or sheeting specimen when sliding over itself or over another substance. The coefficients of friction are related to the slip properties of plastic films that are of wide interest in packaging applications. These methods yield empirical data for control purposes in film production. Correlation...Read More

ASTM F1538 - Standard Specification for Glass and Glass Ceramic Biomaterials for ImplantationASTM International, West Conshohocken, PA, 2009,

Abstract

This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More

ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010,

Significance and Use

This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More

Mach-1 - Friction Testing on a Cartilage Disk or an Osteochondral Core (MA056-SOP08-D v2)Chartrａnd A and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: August 24th, 2015

Purpose
This procedure describes a standard method to realize a friction test on a cartilage disk or an osteochondral core using the Mach-1 TM mechanical tester.

Scope
This procedure can be used for the ex vivo friction test using a planar sliding method on a cartilage disk or an osteochondral...Read More

Mach-1 Analysis - Extraction of Mechanical Parameters Following Friction Testing on a Cartilage Disk or an Osteochondral Core (SW186-SOP07-D v2)Chartrａnd A and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: August 24h, 2015

Purpose
This procedure describes a MatLab-based method to extract mechanical parameters from the Mach-1 result files generated following friction testing on a cartilage disk or an osteochondral core as per MA056-SOP08-D.

Scope
This procedure based on a MatLab code can be applied using any Mach-1 result file obtained following a planar friction...Read More

Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011

Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More

Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)

There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More

Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21

Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017

Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin score, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More

Evaluation of genipin for stabilization of decellularized porcine cartilageElder S, Pinheiro A, Young C, Smith P and Wright EJ Orthop Res. 2016 Nov 18. doi: 10.1002/jor.23483

Abstract

We speculate that an acellular osteochondral xenograft may be a good alternative to allografts for repair of focal articular cartilage lesions. In order to make a xenograft resistant to enzymatic degradation and to prevent a chronic immune response it may beneficial to stabilize it through crosslinking. The concept is analogous to treatment of porcine bioprosthetic heart...Read More

Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428

Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010

In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engineered cartilage. Previous approaches to create the ZCC at the cartilage-substrate interface...Read More

The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)

Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and non-diabetic plantar tissue. Previously compression tested plantar tissue specimens (n = 54) at six relevant plantar locations (hallux, first, third, and fifth...Read More

ASTM C273/C273M - Standard Test Method for Shear Properties of Sandwich Core MaterialsASTM International, West Conshohocken, PA, 2016,

Significance and Use

5.1 The core shear properties are fundamental properties that are used in the design of sandwich panels. This test method provides information on the force-deflection behavior of sandwich constructions or cores when loaded in shear parallel to the plane of the facings. From a complete force-deflection curve, it is possible to compute core shear stress at...Read More

ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010,

Mach-1 - Shear Testing on a Cartilage Disk or an Osteochondral Core (MA056-SOP07-D v2)Tessier J and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: August 25th, 2015

Purpose
This procedure describes a standard method to realize a planar or a torsion shear test on an articular cartilage disk or an osteochondral core using the Mach-1TM mechanical tester.

Scope
This procedure can be used for the ex vivo planar or torsion test on an articular cartilage core or an osteochondral core. It is highly...Read More

Mach-1 Analysis - Extraction of Mechanical Parameters Following Shear Testing on a Cartilage Disk or an Osteochondral Core (SW186-SOP06-D v1)Lavallée APBiomomentum Inc. Laval (QC), Canada, Effective Date: August 19th, 2015

Purpose
This procedure describes a method to extract mechanical parameters from Mach-1 result files generated following shear testing on a cartilage disk or an osteochondral core as per MA056-SOP07-D.

Scope
This procedure can be applied using any Mach-1 result file obtained following a planar shear or a torsion test on a sample. Some...Read More

Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)

Skeletal and epidermal loadings can damage muscle cells and contribute to the development of deep tissue injury (DTI) – a severe kind of pressure ulcers affecting many people with disability. Important predisposing factors include the multiaxial stress and strain fields in the internal tissues, particularly the vulnerable muscles around bony prominences. A careful study of the mechanical damage thresholds...Read More

Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832

Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly developed as new modalities for widely prevalent orthopaedic disorders. Although quality measures for TECP are subject to the same general regulatory quality...Read More

Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576

Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive in vivo techniques, such as magnetic resonance elastography. Results of in vitro and in vivo work are compared, emphasizing the specificities...Read More

Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2018 19 (1), 62-70 doi: 10.1021/acs.biomac.7b01243

We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within one minute after cutting or shear under both neutral...Read More

Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear.Chen J, Brazile B, Prabhu R, Patnaik SS, Bertucci R, Rhee H, Horstemeyer MF, Hong Y, Williams LN, Liao JJ Biomech Eng. 2018 Jul 1;140(7). doi: 10.1115/1.4039825.

In this study, the damage evolution of liver tissue was quantified at the microstructural level under tensile, compression, and shear loading conditions using an interrupted mechanical testing method. To capture the internal microstructural changes in response to global deformation,...Read More

Shear-Deformation Based Continuum-Damage Constitutive Modeling of Brain TissueMark T. Begonia, Alexander M. Knapp, R.K. Prabhu, Jun Liao and Lakiesha N. WilliamsJournal of Biomechanics, 2021, 110260, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.110260

Abstract: Traumatic brain injury (TBI) is a leading cause of death in the United States. Depending on the severity of injury, complications such as memory loss and emotional changes are common. While the exact mechanisms are still unclear, these cognitive deficiencies are thought to arise from microstructural damages to the brain tissue, such as in diffuse-axonal injury where neuron fibers...Read More

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