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珀金埃尔默医学诊断产品（上海）有限公司
珀金埃尔默医学诊断产品（上海）有限公司
AH5183 (vesamicol) radioligａnd tritiated at the piperidinyl-3,4 position. AH5183 is an acetylcholine transport blocker.
AH5183 (vesamicol, (2-hydroxyethyl)-1-piperazine-ethanesulfonic acid, (4-phenylpiperidino) cyclohexanol) is a cholinergic vesicular uptake blocker. Vesicular acetylcholine transporters (VAChT) are neurotransmitter transporters involved in acetylcholine secretion. Vesamicol inhibits the transport of acetylcholine into synaptic vesicles in nerve terminals, and play a role in drug response and vulnerability to drug addiction.
We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.
Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NET964:
| 浓度 | 1.0 - 10 µCi/mL |
|---|---|
| 检测方法 | Radiometric |
| 标签位置 | Specifically Labeled |
| 产品品牌名称 | NEN Radiochemicals |
| 放射性同位素 | H-3 |
| 放射性核素 | 3H |
| 受体类型 | Vesicular Amine Transporters (VATs) |
| 运输条件 | 蓝冰 |
| 特殊订购信息 | This is a radioactive product - shipping address must have a license to receive radioactive materials. |
| 治疗领域 | CNS & Neurologic |
| 产品尺寸 | 250 µCi |
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![AH5183, L-[Piperidinyl-3,4-3H]-(Vesamicol), 250 µCi](https://img79.hbzhan.com/5eceadd4559dcfd26d62455fac166a8617e262c77a9b7f5b4c38d7a69ad1770be9964948a478afc7.jpg)
