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Lysergic Acid Diethylamide, [N-Methyl-3H]-, 250µCi (9.25MBq)

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产品简介

Lysergic Acid Diethylamide (LSD), tritiated on the N-methyl group. LSD is a partial agonist of dopamine D2 receptors. It also binds most serotonin receptors (5-HT1A, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT5A, 5-......

详细介绍

Lysergic Acid Diethylamide (LSD) is a psychedelic drug that acts as an agonist at dopamine D₂ receptors and serotonin receptors 5-HT_1A, 5-HT_2A, 5-HT_2B, 5-HT_2C, 5-HT_5A, 5-HT_5B and 5-HT₆.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET638:

Teresa Riccioni, Fabio Bordi, Patrizia Minetti, Gilberto Spadoni, Hyung-Mun Yun, Bo-Hye Im, Giorgio Tarzia, Hyewhon Rhim, Franco Borsini, ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors, In European Journal of Pharmacology, Volume 661, Issues 1–3, 2011, Pages 8-14.
Rigmor Stain-Malmgren, Bengt F Kjellman, Anna Åberg-Wistedt, Platelet serotonergic functions and light therapy in seasonal affective disorder, In Psychiatry Research, Volume 78, Issue 3, 1998, Pages 163-172.

规格

浓度	1.0 - 10 mCi/mL
检测方法	Radiometric
新鲜的很多天	Second Monday in April, August, and December
标签位置	Specifically Labeled
分子量	323.4
产品品牌名称	NEN Radiochemicals
放射性同位素	H-3
放射性核素	³H
受体类型	5-Hydroxytryptamine
运输条件	干冰
特殊订购信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域	CNS & Neurologic, Cardiovascular, Inflammation, Metabolic Disorders, Gastrointestinal
产品尺寸	250 µCi