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iodo-(±)-Cyanopindolol, [125I], 100µCi

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更新时间:2022-10-15 11:52:50浏览次数:86次

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产品简介

Iodo-(±)-cyanopindolol, labeled with 125I. Cyanopindolol acts as an antagonist at β1 adrenergic receptors and serotonin 5-HT1A receptors.

详细介绍

We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligand binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.

Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NEX174:

  1. Flügge, G., Ahrens, O. & Fuchs, E. (1997) β-Adrenoceptors in the Tree Shrew Brain. II. Time-Dependent Effects of Chronic Psychosocial Stress on [125I]Iodocyanopindolol Binding Sites, Cell Mol Neurobiol 17: 417-432.
  2. Pei, G., Samama, P., Lohse, M., Wang, M., Codina, J., Lefkowitz, R.J. (1994), A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated, PNAS, 91 (7): 2699-2702.

规格

检测方法 Radiometric
新鲜的很多天 First Monday of each month
标签位置 Nominally Labeled
分子量 411.0
产品品牌名称 NEN Radiolabeled Ligands
放射性同位素 I-125
放射性核素 125I
受体类型 Adrenoceptors
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic, Cardiovascular, Metabolic Disorders
产品尺寸 100 µCi

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