当前位置：珀金埃尔默医学诊断产品（上海）有限公司>>>>CGP 39653, [Propyl-2,3,3H]-, 1mCi (37MBq)

CGP 39653, [Propyl-2,3,3H]-, 1mCi (37MBq)

返回列表页

参考价

面议

具体成交价以合同协议为准

产品型号

品牌

厂商性质其他

所在地

在线询价收藏产品查看联系电话

联系方式：查看联系方式

更新时间：2022-10-15 11:58:49浏览次数：70次

联系我时，请告知来自环保在线

产品分类 品牌分类

暂无信息

珀金埃尔默医学诊断产品（上海）有限公司

经营模式：其他

商铺产品：677条

所在地区：

询价 给他留言

产品简介

CGP 39653, tritiated at the propyl-2,3 position. CGP 39653 acts as an N-methyl-D-aspartate (NMDA) antagonist.

详细介绍

CGP 39653 (D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentenoic acid) inhibits the binding of glutatmate to NMDA receptors and binds to rat frontal cortical membranes in a saturable and reversible manner. NMDA receptors are glutamate receptors involved in synaptic plasticity and memory function, and are targets for legal and illicit anesthetic drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1050:

Kawakami, Z., Ikarashi, Y. & Kase, Y. Isoliquiritigenin is a Novel NMDA Receptor Antagonist in Kampo Medicine Yokukansan. Cell Mol Neurobiol (2011) 31: 1203.
Mugnaini, M., Giberti, A., Ratti, E. and van Amsterdam, F. Th. M. (1993), Allosteric Modulation of [3H]CGP 39653 Binding by Glycine in Rat Brain. Journal of Neurochemistry, 61: 1492–1497

规格

浓度	1 mCi/mL
检测方法	Radiometric
标签位置	Specifically Labeled
分子量	237.1
产品品牌名称	NEN Radiochemicals
放射性同位素	H-3
放射性核素	³H
受体类型	Glutamate
运输条件	干冰
特殊订购信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域	CNS & Neurologic, Pain
产品尺寸	1 mCi