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WIN 35428, [N-Methyl-3H]-, 250µCi (9.25MBq)

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珀金埃尔默医学诊断产品（上海）有限公司

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产品简介

WIN 35428 [(–)-2-β-Carbomethoxy-3-β-(4-fluorophenyl)tropane], tritiated on the N-methyl group. WIN 35428 acts as an antagonist at dopamine transporters (DATs).

详细介绍

WIN 35428 is a dopamine reuptake inhibitor, and is a stimulant drug. These transporters are potential drug targets for attention deficit hyperactivity disorder (ADHD), bipolar disorder, clinical depression, and alcohol addiction.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (B_max), dissociation constants (K_d), association and dissociation rates (k_on and k_off), and inhibitor constants (K_i) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET1033:

Hong, W.C., Yano, H., Hiranita, T., Chin, F.T., McCurdy, C.R., Su, T., Amara, S.G., Katz, J.L., The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats. Journal Biological Chemistry, 2017, 292 (27): 11250-11261.
Hong, W.C., and Amara, S.G., Membrane Cholesterol Modulates the Outward Facing Conformation of the Dopamine Transporter and Alters Cocaine Binding. Journal of Biological Chemistry, 2010, 285 (42): 32616-32626.

规格

浓度	1.0 - 10 mCi/mL
检测方法	Radiometric
标签位置	Specifically Labeled
分子量	277.3
产品品牌名称	NEN Radiochemicals
放射性同位素	H-3
放射性核素	³H
受体类型	Dopamine
运输条件	干冰
特殊订购信息	This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域	CNS & Neurologic
产品尺寸	250 µCi