Description
Biochem/physiol Actions Tobramycin is an aminoglycoside.
Mode of Action: Binds to 70S ribosomal subunit; inhibits translocation; elicits miscoding.
Spectrum of Activity: Gram negative bacteria. Not effective against Enterococci.
Properties
storage temp. 2-8°C
Safety
WGK Germany 2
RTECS WK2100000
References
reference Hobbie, S.N., et al., Analysis of the contribution of individual substituents in 4,6-aminoglycoside-ribosome interaction. Antimicrob. Agents Chemother. 49, 5112-5118, （2005）
Walter, F., et al., Binding of tobramycin leads to conformational changes in yeast tRNA（Asp） and inhibition of aminoacylation. EMBO J. 21, 760-768, （2002）
Merck Merck 13,9567
Beilstein Beil. 18,V,11,259
Printable Reviews
Product ReviewsReview This Product
Overall: 5 out of 5
Anonymous
Location: Santa Barbara, CA
Research Experience: 6-10
Purchasing Frequency: Weekly
Education: Master's
Primary Field: Life ScienceGood SolubilityApril 7, 2010
"This antibiotic is very soluble in water. We have been using it to do experiments with an aptamer that binds aminoglycosides. It works quite well for that purpose."
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