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Description
Biochem/physiol Actions Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.
Mode of Action: Inhibits folic acid synthesis in prokaryotes.
Anti-microbial Spectrum: Gram positive, Gram negative, Chlamydia
Mode of Resistance: Alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis.
Properties
assay ≥99.0%
mp 253 °C (dec.)(lit.)
suitability suitable for 1694 per US EPA
Safety
Personal Protective Equipment dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Hazard Codes Xn
Risk Statements 22-36/37/38-42/43
Safety Statements 26-36
WGK Germany 3
RTECS WP1925000
References
reference Then, R.L., Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole. Rev. Infect. Dis. 4, 261-269, (1982) Abstract
Skold, O., Sulfonamide resistance: mechanisms and trends. Drug Resist. Updat. 3, 155-160, (2000) Abstract
Merck Merck 13,8988
Beilstein Beil. 25,IV,2097
Corp MSDS 1 (2), 3195:A / FT-IR 2 (3), 3872:A / FT-NMR 1 (3), 392:A / RegBook 1 (2), 2587:C / Sax 6, 2338 / Sigma FT-IR 1 (1), 713:D / Structure Index 1, 409:C:4
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