Description
Biochem/physiol Actions GTP functions as a carrier of phosphates and pyrophosphates involved in channeling chemical energy into specific biosynthetic pathways. GTP activates the signal transducing G proteins which are involved in various cellular processes including proliferation, differentiation, and activation of several intracellular kinase cascades. Proliferation and apoptosis are regulated in part by the hydrolysis of GTP by small GTPases Ras and Rho. Another type of small GTPase, Rab, plays a role in the docking and fusion of vesicles and may also be involved in vesicle formation. In addition to its role in signal transduction, GTP also serves as an energy-rich precursor of mononucleotide units in the enzymatic biosynthesis of DNA and RNA.
Preparation Note Prepared by enzymatic phosphorylation of 5′-GMP.

Properties
assay ≥95% （HPLC）
form powder
color white
solubility H2O: 50 mg/mL
Gene Information human ... HRAS（3265）
shipped in dry ice
storage temp. −20°C

Safety
Personal Protective Equipment Eyeshields, Faceshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Hazard Codes T
Risk Statements 36/37/38-39/23/24/25
Safety Statements 26-36/37/39-45
WGK Germany 3

References
reference Gutkind, J.S., Cell growth control by G protein-coupled receptors: from signal transduction to signal integration. Oncogene 17, 1331-1342, （1998）
  Dhanasekaran, N., et al., Regulation of cell proliferation by G proteins. Oncogene 17, 1383-1394, （1998）
  Hepler, J.R., and Gilman, A.G., G proteins. Trends Biochem. Sci. 17, 383-387, （1992） Abstract
  Gomez, J., et al., Dual role of Ras and Rho proteins: at the cutting edge of life and death. Immunol. Cell Biol. 76, 125-134, （1998）
  Lacal, J.C., Regulation of proliferation and apoptosis by Ras and Rho GTPases through specific phospholipid-dependent signaling. FEBS Lett. 410, 73-77, （1997）
  Schimmoller, F., et al., Rab GTPases, directors of vesicle docking. J. Biol. Chem. 273, 22161-22164, （1998）
  Woodman, P., Vesicle transport: more work for the Rabs?. Curr. Biol. 8, R199-R201, （1998）

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