Stemolecule™ CHIR99021（GSK-3β抑制剂） 生化试剂 返回列表页

Stemolecule™ CHIR99021（GSK-3β抑制剂）

产品关键词：

GSK-3β；naïve stem cells 初始干细胞；neural progenitor cells 神经祖细胞；WH-4-023；Y27632；PD0325901；CAS：252917-06-9；

产品描述：

氨基嘧啶CHIR99021是目前为止报道的选择性zui强的GSK-3β抑制剂。与其他强效的GSK-3抑制剂相比，CHIR99021不会交叉抑制细胞周期蛋白依赖性激酶（CDKs），对GSK-3β的选择性是对CDKs的350倍。与抑制MAPK来源的分化诱导信号联合，使用CHIR99021阻断 GSK-3β信号使得胚胎干细胞能自我更新。

产品特性

1. 同义名：6-[[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2 pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile

2. 分子式：C₂₂H₁₈Cl₂N₈

3. 分子量：465.34 g/mol

4. CAS NO：252917-06-9

5. 纯度：＞95%（HPLC）

6. 外观：Off-white solid

7. 溶解性：DMSO

8. 保存和稳定性：粉末4 °C避光保存，重溶后的储存液分装后-20 °C保存，6个月稳定。

9. 质量控制：HPLC测定纯度，MS测定准确分子量，CHIR99021对小鼠胚胎干细胞的细胞毒性测试。

10. 结构图：

订购信息：原装正品，欢迎订购，：，：。

引用文献：

• Xia N; Zhang P; Fang F; Wang Z; Rothstein M; Agulo B; Chiang R; Taylor J; Reijo Pera RA. "Transcriptional comparison of human induced and primary midbrain dopaminergic neurons." Scientific Reports. 6:20270. doi:10.1038/srep20270 (2016)

• Han Y-C, Lim Y; Duffieldl MD; Liu J; Manaph NPA; Yang M; Keating DJ; Zhou X-F. "Direct reprogramming of mouse fibroblasts to neural stem cells by small molecules." Stem Cells International 2016:4304916 (2016)

• Zhu S; Russ HA; Wang X; Zhang M; Ma T; Xu T; Tang S; Hebrok M; Deng S. "Human pancreatic beta-like cells converted from fibroblasts." Nature Commun 7:10080 (2016)

• Titmarsh DM; Glass NR; Mills RJ; Hidalgo A; Volvetang EJ; Porrello ER; Hudson JE; Cooper-White JJ. "Induction of human iPSC-derived cardiomyocyte proliferation revealed by combinatorial screening in high density microbioreactor arrays." Sci Rep 6:24637 (2016)

• Liu G. "No detection of potential cancer risk for free-viral reprogrammed stem cell-derived dopaminergic neurons from adult mice fibroblasts." J Stem Cell Res Ther 5:286 (2015)

• Fonoudi H; Ansari H; Abbasalizadeh S; Laruani MR; Kiani S; Hashemizadeh S; Zarchi AS; Bosman A; Blue GM; Pahlavan S; Perry M; Orr Y; Mayorchak Y; Vandenberg J; Talkhabi M; Winlaw SD; Harvey RP; Aghdami N; Baharvand H. "A universal and robust integrated platform for the scalable production of human coardiomhyocytes from pluripotent stem cells." Stem Cells Trans Med 4:1482 (2015)

• Yang J; Kaur K; Ong LL; Eisenberg CA; Eisenberg LM. "Inhibition of G9a histone methyltransferase converts bbone marrow mesenchymal stem cells to cardiac competent progenitors." Stem Cells International Article 270428 (2015) doi:10.1155/2015/270428

• Ren J; Briones V; Barbour S; Yu W; Han Y; Tarashima M; Muegge K. "The ATP binding site of the chromatin remodeling homolog LSH is required for nucleosome density and de novo DNA methylation at repeat sequences." Nucl Acids Res doi: 10.1093/nar/gku1371 (2015)

• DeRosa BA; Belle KC; Thomas BJ; Cukier HN; Pericak-Vance MA; Vance JM; Dykxhoom DM. "hVGAT-mCherry: A novel molecular tool for analysis of GABAergic neurons derived from human pluripotent stem cells." Mol Cell Neurosci 68:244 (2015)

• Tan H-K; Toh C-XDl Ma D; Yang B; Liu TM; Lu J; Wong C-W; Tan T-K; Li H; SYn C; Tan E-L; Lim B; Lim Y-P; Cook SA; Loh Y-H. "Human finger-prick induced pluripotent stem cells facilitate the development of stem cell banking." Stem Cells Trans Medicine 3:586 (2014)

• Ying, Q., Tai, C. Gbx2, a LIF/Stat3 target, promotes reprogramming to and retention of the pluripotent ground state. Journal of Cell Science 126, 1093 – 1098.(2013)

• Youn H; Kim S-H; Choi KA; Kim S. "Characterization of Oct4-GFP spermatogonial stem cell line and its applicationo in the reprogramming studies." J Cell Biochem 114:920 (2013)

• Blauwkamp TA; Nigam S; Ardehali R; Weissman IL; Nusse R. Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors. Nature Communications 3:1070 (2012).

• Lian, X., Hsiao, C., Wilson, G, Zhu, K., Hazeltine, L.B., Azarin, S.M., Raval, K.K., Zhang, J., Kamp, T.J., and Palecek, S.P. (2012) Robust cardiomyocyte differentiation from human pluripotent stem cells via temporal modulation of canonical Wnt signaling. Proc Natl Acad Sci USA 109: E1848 (2012)

• Moraveji S-F; Attari F; Shahverdi A; Sepehri H; Farrokhi A; Hassani S; Fonoudi H; Aghdami N; Baharvand H. "Inhibition of glycogen synthase kinase-3 promotes efficient derivation of pluripotent stem cells from neonatal mouse testis." Human Reproduction 27:2312 (2012)

• Nagy, K., Sung, H-K., Zhang, P., Laflamme, S., Vincent, P, Agha-Mohammadi, S., Woltjen, K., Monetti, C., Michael, I. P., Smith, L. C., Nagy, A. Induced Pluripotent Stem Cell Lines Derive from Equine Fibroblasts. Stem Cell Reviews and Reports 7:693 (2011).

• Wang, B., Miyagoe-Suzuki, Y., Yada, E., Ito, N., Nishiyama, T., Nakamura, M., Ono, Y., Motohashi, N., Segawa, M., Masuda, S., Takeda, S. Reprogramming Efficiency and Quality of Induced Pluripotent Stem Cells (iPSCs) Generated from Muscle-derived Fibroblasts of MDX Mice at Different Ages. PLOS Currents Muscular Dystrophy. 2011 Oct 27 . Edition 1. doi: 10.1371/currents.RRN1274 .

• Mack, A., Kroboth, S., Rajesh, D., Wang, W. B. Generation of Induced Pluripotent Stem Cells from CD34+ Cells across Blood Drawn from Multiple Donors with Non-Integrating Episomal Vectors. PLoS One; 6(11): e27956.(2011)

• Li, W., Zhou, H., Abujarour, R., Zhu, S., Young Joo, J., Lin, T., Hao, E., Schöler, H.R., Hayek, A., Ding, S. (2009) Generation of human-induced pluripotent stem cells in the absence of exogenous Sox2. Stem Cells 27: 2992-3000.

• Chiang P-M; Wong PC. "Differentiation of an embryonic stem cell to hemogenic endothelium by defined factors: Essential role of bone morphogenetic protein 4." Development 138: 2833-2843 (2011)

— —Written/Edited by V. Shallan【版权归MKBio懋康所有】

上海懋康生物科技有限公司是一家涉足于生命科学和生物技术领域研究的试剂、仪器和实验室消耗品与实验服务工作，主要从事细胞生物学、植物学、分子生物学、免疫学、生物化学、蛋白组学。生物制药与诊断试剂研发生产等领域。 本公司秉承“以人为本，以诚为信、合同守信"的经营理念。坚持"品质保障"的原则为广大客户提供优质产品。

Stemolecule™ CHIR99021（GSK-3β抑制剂）

Stemolecule™ CHIR99021（GSK-3β抑制剂）

Stemolecule™ CHIR99021（GSK-3β抑制剂）