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当前位置:珀金埃尔默医学诊断产品(上海)有限公司>>>>SR 95531, [Butyryl-2,3-3H]-, 250µCi (9.25MBq)

SR 95531, [Butyryl-2,3-3H]-, 250µCi (9.25MBq)

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更新时间:2022-10-14 14:37:09浏览次数:75次

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产品简介

SR-95531 (Gabazine), tritiated at the butyryl-2,3 position. SR-95531 acts as an antagonist at GABAA receptors.

详细介绍

SR-95531 acts as an antagonist at GABAA receptors. These receptors are ligand-gated ion channels and are the target for many psychoactive drugs.

We offer both agonist and antagonist radioligands for autoradiographic visualization or performing saturation and competition assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radioligands is fully characterized for pharmacological action and validated in receptor binding assays.

Radiolabeled ligands remain the most sensitive method for probing receptor binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New England Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.

References for NET946:

  1. Yanlin Lei, Irene Yaroslavsky, Shanaz M. Tejani-Butt, Strain differences in the distribution of N-methyl-d-aspartate and gamma (γ)–aminobutyric acid-A receptors in rat brain, Life Sciences, Volume 85, Issues 23–26, 2009, Pages 794-799.
  2. Jon E. Hawkinson, Manuel Acosta-Burruel, Catherine L. Kimbrough, Dayan B. Goodnough, Paul L. Wood, Steroid inhibition of [3H]SR 95531 binding to the GABAA recognition site, European Journal of Pharmacology, Volume 304, Issues 1–3, 1996, Pages 141-146.

规格

浓度 1.0 - 10 mCi/mL
检测方法 Radiometric
标签位置 Specifically Labeled
分子量 287.3
产品品牌名称 NEN Radiochemicals
放射性同位素 H-3
放射性核素 3H
受体类型 Benzodiazepine, GABAA
运输条件 干冰
特殊订购信息 This is a radioactive product - shipping address must have a license to receive radioactive materials.
治疗领域 CNS & Neurologic
产品尺寸 250 µCi

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