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5ug重组人4-1BB配体,Human 4-1BBL
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- 上海高创化学科技有限公司
- 2015-12-28 09:39:47
- 上海市
- 以色列
- 426
【简单介绍】
【详细说明】
| Catalogue Number | CYT-149 | |||
| Synonyms | CD137L, CD137-L, 4-1BBL, 4-1BB Ligand, TNFSF9, Tumor Necrosis Factor （ligand） Superfamily Member 9. | |||
| Introduction | 4-1BBL is a transmembrane cytokine that is part of the tumor necrosis factor （TNF） ligand family. 4-1BBL is a bidirectional signal transducer that performs as a ligand for TNFRSF9, which is a costimulatory receptor molecule in T lymphocytes. TNFSF9 and its TNFRSF9 take part in the antigen presentation development and in the generation of cytotoxic T cells. 4-1BBR is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. TNFSF9 reactivates anergic T lymphocytes as well as promoting T lymphocyte proliferation. 4-1BB Ligand is needed for the optimal CD8 responses in CD8 T cells. 4-1BBL is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. 4-1BBL is expressed by activated B cells, macrophages, dendritic cells, activated T cells, neurons and astrocytes. The interaction of 4-1BB with TNFRSF9 strongly regulates immunity and has been proposed to preferentially control T cell responses based on studies in various murin. | |||
| Description | 4 1BBL Human Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 184 amino acids and having a molecular mass of 19.5kDa. The 4 1BBL is purified by proprietary chromatographic techniques. | |||
| Source | Escherichia Coli. | |||
| Physical Appearance | Sterile Filtered White lyophilized （freeze-dried） powder. | |||
| Formulation | Lyophilized from a 0.2?m filtered concentrated solution in PBS, pH 7.4. | |||
| Solubility | It is recommended to reconstitute the lyophilized 4 1BBL in sterile 18M?-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions. | |||
| Stability | Lyophilized 4 1BBL although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution 4 1BBL should be stored at 4°C between 2-7 days and for future use below -18°C. Please prevent freeze-thaw cycles. | |||
| Purity | Greater than 95.0% as determined by SDS-PAGE. | |||
| Amino acid sequence | REGPELSPDD PAGLLDLRQG MFAQLVAQNV LLIDGPLSWY SDPGLAGVSL TGGLSYKEDT KELVVAKAGV YYVFFQLELR RVVAGEGSGS VSLALHLQPL RSAAGAAALA LTVDLPPASS EARNSAFGFQ GRLLHLSAGQ RLGVHLHTEA RARHAWQLTQ GATVLGLFRV TPEIPAGLPS PRSE | |||
| Biological Activity | Fully biologically active when compared to standard. Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10ng/ml corresponding to a Specific Activity of 100,000-200,000IU/mg. | |||
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | |||
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