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100ug重组乙肝病毒抗原|HBcAg Core （1-186）
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- 上海高创化学科技有限公司
- 2016-06-04 15:19:24
- 上海市
- 563
【简单介绍】
【详细说明】
| Introduction | Hepatitis B is one of a few known non-retroviralviruses which employ reverse transcriptionas a part of its replication process. （HIV, a compley unrelated virus, also uses reverse transcription, but it is a retrovirus.） HBV invades the cell by binding to surface receptor and become internalized. The viral core particles then migrate to the hepatocyte nucleus and the partially double-stranded, relaxed circular genomes （RC-DNA） are repaired to form a covalently closed circular DNA （cccDNA）, which is the template for viral genomic and sub-genomic RNAs by cellular RNA polymerase II. Of these, the pregenomic RNA（pgRNA is selectively packaged into progeny capsids and is then reverse-transcribed into new RC-DNA. The core can either bud into the endoplasmic reticulum to be enveloped or exported from the cell or recycled back into the genome for conversion to cccDNA. | ||||||||
| Description | The E.coli derived recombinant protein contains the HBV core immunodominant region amino acids 1-186, and fused to a His tag at N- terminus. | ||||||||
| Purification Method | HBV Core protein was purified by proprietary chromatographic technique. | ||||||||
| Purity | HBV Core protein is >90% pure as determined by 10% PAGE （Coomassie staining）. | ||||||||
| Formulation | 25mM Tris-HCl pH-8.0, 1.5mM Urea & 50% glycerol. | ||||||||
| Storage | HBV Core protein although stable at 4°C for 1 week, should be stored below -18°C. Please prevent freeze thaw cycles. | ||||||||
| Specificity | Immunoreactive with sera HBV-infected individuals. | ||||||||
| Applications | HBV Core antigen is suitablr for ELISA and Western blots, excellent antigen for detection of HBV with minimal specificity problems. | ||||||||
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||||||||
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