Rabbit Anti-PEG10 RF1

【资料简介】

上海瑞齐生物科技有限公司：
 
订货： 60513568    
Rabbit Anti-PEG10 RF1
（Paternally expressed gene 10 RF1）
     
Catalog Number :   RS-1084R
 
Quantity size :   0.2ml  （dilute with pH 7.4  0.01 M PBS or antibody diluent ）
 
Background:   PEG10 （Paternally expressed gene 10） inhibits TGF beta signaling by interacting with the TGF beta receptor ALK1. It is able to prevent apoptosis in hepatocellular carcinoma （HCC） cells through interaction with SIAH1, a mediator of apoptosis. PEG10 is a mammalian gene that has been shown to be essential for embryonic development and is highly conserved in therian mammals. PEG10 has evolved from a retroelement into a gene that is  required during prenatal development and has maintained its ability to carry out –1 frameshifting to express two proteins from the same mRNA （ORF1 and ORF2）. This is the first demonstration of –1 frameshifting for gene expression in animal tissues and is the highest frameshift efficiency reported.
            
Specificity :    •anti-PEG10 RF1 is a rabbit polyclonal antibody unconjugated
                •specific for PEG10 RF1 of human, mouse, rat   
                •broadly reactive with mammalian species 
                •epitope mapping near the amino terminus of PEG10RF1 of human, mouse,rat,  
                •use for western blotting, elisa, immunoprecipitation  
                   and immunohistochemistry
• Protein G affinity chromatography purification, purity :>95%
• Isotype: IgG
• mol wt: 42kDa
 
Application:    •Western blotting 1:100-500
                •Immunohistochemistry 1:100-500
                •ELISA 1:500-1000
                • Optimal working dilutions must be determined by the end user.
 
Storage:     Store at –20 ºC for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20ºC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody, the antibody is stable for at least two weeks at 2-4 ºC.
Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.